Results 111 to 120 of about 340,267 (341)

Assessment of Pharmacokinetic Drug Interaction of Asciminib with Atorvastatin in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Asciminib is the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP) in patients with chronic myeloid leukemia. This phase 1, two‐treatment‐period, drug‐drug interaction study evaluated the effect of steady‐state asciminib on the pharmacokinetics of atorvastatin.
Matthias Hoch, Wendy Weis, Felix Huth, Seshulatha Jamalapuram, Michelle Quinlan, Amarnath Bandaru, Suleyman Eralp Bellibas, Asmae Mirkou, Shruti Kapoor, Shefali Kakar   +9 more
wiley   +1 more source

Negative association between body roundness index and constipation: insights from NHANES

Journal of Health, Population and Nutrition
Backgrounds The relationship between body roundness index (BRI), a metric that distinguishes heterogeneity in fat distribution, and constipation is unclear.
Lingting Chen, Huirong Xiao, Xuchao Yu, Bingbin Huang, Sirong Guo, Ting Yuan, Siyang Deng   +6 more
doaj   +1 more source

A Phase 1, Randomized, Placebo‐Controlled, Multiple‐Dose, Double‐Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This Phase 1, randomized, placebo‐controlled, double‐blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1 ...
Rajinder Bhardwaj, Chay Ngee Lim, Yinhua Li, Kyle T. Matschke, Richard Bertz, Robert Croop, Jing Liu   +6 more
wiley   +1 more source

The Prevalence and Burden of Avoidant/Restrictive Food Intake Disorder (ARFID) Symptoms in the Adult General Population of the UK and USA

International Journal of Eating Disorders, EarlyView.
ABSTRACT Introduction Avoidant/Restrictive Food Intake Disorder (ARFID) is a feeding and eating disorder characterized by avoidant/restrictive eating behaviors that lead to medical and/or functional impairments. While ARFID is increasingly recognized within pediatric populations and specialist clinics, data on its prevalence and burden within the adult
Grace Brownlow, Rosie Flack, Helen Burton‐Murray, Olafur Palsson, Imran Aziz   +4 more
wiley   +1 more source

A modern view of the problem of constipation

Лечащий Врач
Background. PA new chronomedical approach to the classification of one of the most common syndromes in modern medicine, the constipation syndrome, is presented. According to Robert Hegglin "сonstipation is the absence of defecation for 24 hours".
Konstantin A. Shemerovskii, Raisa K. Kantemirova, Pavel V. Seliverstov   +2 more
doaj   +1 more source

Frequency patterns of core constipation symptoms among the Asian adults: a systematic review

BMC Gastroenterology, 2017
Background In clinical practice, assessment of constipation depends on reliability, consistency and frequency of several commonly reported or core symptoms.
Abdul Wahab Patimah, Yeong Yeh Lee, Mohd Yusoff Dariah   +2 more
doaj   +1 more source

CONSTIPATION SCORING SYSTEM VALIDATED FOR THE PORTUGUESE LANGUAGE (ÍNDICE DE GRAVIDADE DA CONSTIPAÇÃO INTESTINAL): IS IT RELIABLE IN ASSESSING THE SEVERITY OF INTESTINAL CHRONIC CONSTIPATION IN OUR POPULATION?

, 2023
Ilário Froehner, José Márcio Neves Jorge, Carlos Frederico Sparapan Marques, Vera Lúcia Conceição de Gouveia Santos, José Jukemura   +4 more
openalex   +1 more source

Electro‐clinical features of Mowat–Wilson syndrome: A retrospective study of 31 children in mainland China

Epileptic Disorders, EarlyView.
Abstract Objective To summarize the electro‐clinical and genetic characteristics of children with Mowat–Wilson syndrome (MWS). Methods This study is a hospital‐based case series analyzing clinical data from 31 pediatric patients with MWS and epilepsy treated at Peking University First Hospital between June 2020 and December 2024.
Yi Ju, Tao‐yun Ji
wiley   +1 more source

Comparison of three with six regions of interest analyses in patients with idiopathic constipation undertaking colon transit scintigraphy using 67Ga-citrate [PDF]

, 2013
OBJECTIVE AND INTRODUCTION: Preparation of data from 6 geometric regions of interest in the colon is time consuming, and can become impractical in the environment of busy Nuclear Medicine Departments.
Asli, I.N., Assadi, M., Ehsani, M.J., Javadi, H., Semnani, S., Tabib, S.M.   +5 more
core  

Weaning from ketogenic diet therapy in children with epilepsy: Insights from a retrospective study

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to describe weaning practices following ketogenic diet therapy (KDT) in children with epilepsy and to identify clinical factors associated with seizure exacerbation or antiseizure medication adjustments during or after weaning from KDT.
Noémie Donnard, Blandine Dozières‐Puyravel, Katia Geraldes, Céline Perrot, Virginie Quéméner, Estelle Goujon, Pierre Truchy, Hala Nasser, François‐Xavier Mauvais, Marion Danse, Stéphane Auvin   +10 more
wiley   +1 more source