Results 121 to 130 of about 312,671 (350)

First‐in‐Human Single and Multiple Ascending Dose Studies of Balinatunfib, a Small Molecule Inhibitor of TNFR1 Signaling in Healthy Participants

Clinical Pharmacology &Therapeutics, EarlyView.
Oral small molecule inhibitors of tumor necrosis factor alpha (TNFα) are emerging as attractive therapeutic agents for the treatment of various autoimmune diseases. Balinatunfib (SAR441566), a novel oral inhibitor of tumor necrosis factor receptor 1 (TNFR1) signaling, changes the configuration of the soluble TNFα (sTNFα) trimer and prevents its ...
Nassr Nassr, Faiza Rharbaoui, Dietmar Weitz, Johann Gassenhuber, Markus Rehberg, Markus Kohlmann, Fabienne Schumacher, Amel Lahmar, Andreas Kovar, Laurent Perrin, Frank‐Dietrich Wagner, Maria Wiekowski, Mai Anh Nguyen   +12 more
wiley   +1 more source

Association between constipation and incident chronic kidney disease in the UK Biobank study

Scientific Reports
Despite previous studies supporting a close relationship between constipation and chronic kidney disease (CKD), the potential impact of constipation on incident CKD and the role of laxatives remains uncertain.
Kipyo Kim, Won-Hee Cho, Seun Deuk Hwang, Seoung Woo Lee, Joon Ho Song   +4 more
doaj   +1 more source

CONSTIPATION AND INTESTINAL INFECTION IN EPILEPTICS [PDF]

, 1916
Charles A. Reed
openalex   +1 more source

The Irritable Bowel Syndrome [PDF]

, 2009
A 45 year old businessman presents at your clinic with a 2 year history of recurrent abdominal pain, associated with frequent bouts of diarrhoea. The pain is relieved by defaecation, but there is often a feeling of incomplete evacuation.
Zammit, Edward
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The National Academies’ 2024 Diagnostic Criteria for Long COVID: Concerns That Could Affect the Rheumatology Community

Arthritis &Rheumatology, EarlyView.
Leonard H. Calabrese, Michael Putman, Jeffrey A. Sparks, Zachary Wallace, Alfred H. J. Kim, Kevin L. Winthrop, Cassandra Calabrese   +6 more
wiley   +1 more source

Real‐world effectiveness and tolerability of cenobamate in drug‐resistant epilepsy: A retrospective analysis of the patients included into the Early Access Programs (EAP) in Germany, France, and United Kingdom

Epilepsia Open, EarlyView.
Abstract Objective Investigate real‐world outcomes in drug‐resistant epilepsy (DRE) patients treated with cenobamate as adjunctive treatment to other antiseizure medications (ASMs) within the Early Access Programs (EAP) in Germany, France, and the United Kingdom.
Sylvain Rheims, Bernhard J. Steinhoff, Edouard Hirsch, Felix Rosenow, Arnaud Biraben, Rhys Thomas, Alessandro Lovera, Paola Lipone, Alessandro Comandini, Caroline Benoist, Elena Alvarez Baron, John Paul Leach, Karthinathan Thangavelu, Agnese Cattaneo   +13 more
wiley   +1 more source

A CASE OF LONG-STANDING CONSTIPATION [PDF]

, 1905
H. Grey
openalex   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

The effect of mother’s and infant nutrition on functional constipation in children between 1-4 months

Trends in Pediatrics
Objective: Constipation is the infrequent and painful passage of hardened stools, occurring less than three times a week, often accompanied by excessive straining and discomfort.
Gülberat Totur, Maşallah Baran
doaj   +1 more source

Hubungan Antara Asupan Serat Dengan Kejadian Konstipasi Pada Pekerja Di PT. Tiga Serangkai Surakarta [PDF]

, 2016
Background: Constipation is defecation in the form of less frequent bowel movement, unsatisfied sensation to defecate, painful to defecate, and hard stools consistency.
, Elida Soviana, S.Gz., M.gizi, , Siti Zulaekah, A., M.si, Wulandari, Mayriza   +2 more
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