Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef+10 more
wiley +1 more source
Chronic Lung Diseases and Depressive Symptoms in Older Adults: Insights from Observational Studies and Mendelian Randomization. [PDF]
Liu H+8 more
europepmc +1 more source
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon+13 more
wiley +1 more source
Exposing Selection and Genetic Linkage in the Evolutionary Enigmatic Balanced Lethal System in <i>Triturus</i> Newts. [PDF]
Meilink WRM+7 more
europepmc +1 more source
On the Connection between Chemical Constitution and Physiological Action:—On the Physiological Action of the Salts of Ammonia, of Tri-niethylamine, and of Tetramethyl-ammonium; of the Salts of Tropia, and of the Ammonium Bases derived from it; and of Tropic, Atropic, and Isatropic Acids and their Salts. With further details on the Physiological Action of the Salts of Methyl-Strychnium and of Ethyl-Strychnium [PDF]
A. Crum Brown, Thomas R. Fraser
openalex +1 more source
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo+11 more
wiley +1 more source
Unlocking the promise of UK health data: considering the case for a charitable GP data trust. [PDF]
Redhead CAB+6 more
europepmc +1 more source