On the Connection between Chemical Constitution and Physiological Action:—On the Physiological Action of the Salts of Ammonia, of Tri-niethylamine, and of Tetramethyl-ammonium; of the Salts of Tropia, and of the Ammonium Bases derived from it; and of Tropic, Atropic, and Isatropic Acids and their Salts. With further details on the Physiological Action of the Salts of Methyl-Strychnium and of Ethyl-Strychnium [PDF]
A. Crum Brown, Thomas R. Fraser
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The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity
Molecular Oncology, EarlyView.Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause +6 more
wiley +1 more source
Vertical Technologies and Relational Values: Rethinking Ethics of Technology in an Age of Extractivism. [PDF]
Philos TechnolHopster J.
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Molecular Oncology, EarlyView.Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
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Gut microbial characteristics of the damp-heat constitution: a population-based multicenter cross-sectional study. [PDF]
J Tradit Chin MedTianxing LI +11 more
europepmc +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
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Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Chloride as a Partial Nitrate Substitute in Hydroponics: Effects on Purslane Yield and Quality. [PDF]
Plants (Basel)Spyrou GP +9 more
europepmc +1 more source
Constitutional Traditions and Constitutional Transitions
Belov, Martin, Florczak-Wątor, Monika
openaire +2 more sources
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source