Results 41 to 50 of about 15,029 (242)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Tests of Gravity Using Lunar Laser Ranging
Living Reviews in Relativity, 2010 Lunar laser ranging (LLR) has been a workhorse for testing general relativity over the past four decades. The three retroreflector arrays put on the Moon by the Apollo astronauts and the French built arrays on the Soviet Lunokhod rovers continue to be ...
Stephen M. Merkowitz
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Post-Newtonian Approximation for Relativistic Compact Binaries
Living Reviews in Relativity, 2007 We discuss various aspects of the post-Newtonian approximation in general relativity. After presenting the foundation based on the Newtonian limit, we show a method to derive post-Newtonian equations of motion for relativistic compact binaries based on a
Futamase Toshifumi, Itoh Yousuke
doaj
12С(15N, 14С) 13N reaction mechanisms at energy 81 MeV and 14С + 13N nuclei interaction
Ядерна фізика та енергетика, 2019 The 12С(15N, 14С)13N reaction at the energy Еlab(15N) = 81 MeV for ground and excited states of 14С and 13N nuclei was investigated. New experimental data of the reaction cross-sections were obtained.
А. Т. Rudchik +18 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
On the Persistence of Homogeneous Matter [PDF]
, 2004 Some recent philosophical debate about persistence has focussed on an argument against perdurantism that discusses rotating perfectly homogeneous discs (the `rotating discs argument'; RDA). The argument has been mostly discussed by metaphysicians, though
Butterfield, Jeremy +2 more
core
The Motion of Point Particles in Curved Spacetime
Living Reviews in Relativity, 2004 This review is concerned with the motion of a point scalar charge, a point electric charge, and a point mass in a specified background spacetime. In each of the three cases the particle produces a field that behaves as outgoing radiation in the wave zone,
Poisson Eric
doaj
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Causation at different levels : Tracking the commitments of mechanistic explanations [PDF]
, 2011 This paper tracks the commitments of mechanistic explanations focusing on the relation between activities at different levels. It is pointed out that the mechanistic approach is inherently committed to identifying causal connections at higher levels with
Fazekas, Péter
core +1 more source