Results 41 to 50 of about 151,821 (357)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Prioritised fuzzy constraint satisfaction problems: axioms, instantiation and validation [PDF]

, 2003
This paper identifies a generic axiom framework for prioritised fuzzy constraint satisfaction problems (PFCSPs), and proposes methods to instantiate it (i.e., to construct specific schemes which obey the generic axiom framework).
Luo, X., Jimmy Ho-man Lee, Lee, JH, Lee, JH-M, Luo, X, Leung, H, Jennings, N. R., Nicholas R. Jennings, Xudong Luo, Ho-fung Leung, Leung, H., Leung, H-F, Jennings, NR, Luo, Xudong, Lee, J.H.   +14 more
core   +1 more source

Secure transmission for NOMA downlink based on short packet communication

Tongxin xuebao, 2021
For the low-latency requirements of Internet of things (IoT) business, short packet communication (SPC) and non-orthogonal multiple access (NOMA) were combined to study the problem of secure transmission in the multi-user NOMA system with eavesdroppers ...
Gangcan SUN, Shaoke ZHAO, Wanming HAO, Zhengyu ZHU   +3 more
doaj   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

An efficient graph algorithm for dominance constraints [PDF]

Journal of Algorithms, 2003
Summary: Dominance constraints are logical descriptions of trees that are widely used in computational linguistics. Their general satisfiability problem is known to be NP-complete. Here we identify normal dominance constraints and present an efficient graph algorithm for testing their satisfiability in deterministic polynomial time.
Althaus, Ernst, Duchier, Denys, Koller, Alexander, Mehlhorn, Kurt, Niehren, Joachim, Thiel, Sven   +5 more
openaire   +4 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Path Tracking Control Based on Model Predictive Control With Adaptive Preview Characteristics and Speed-Assisted Constraint

IEEE Access, 2020
As one of the research focuses in the field of intelligent driving, improving the performance of path tracking has become a goal for many scholars. Among many path tracking control algorithms, model predictive control (MPC) controllers are widely used ...
Changhua Dai, Changfu Zong, Guoying Chen
doaj   +1 more source

Energy-Efficient Trajectory Optimization for UAV-Based Hybrid FSO/RF Communications with Buffer Constraints

Entropy, 2021
This paper focuses on an unmanned aerial vehicle (UAV) assisted hybrid free-space optical (FSO)/radio frequency (RF) communication system. Considering the rate imbalance between the FSO and RF links, a buffer is employed at the UAV.
Rong-Rong Lu, Yang Ma, Sheng-Hong Lin, Bingyuan Zhang, Qinglin Wang, Jin-Yuan Wang   +5 more
doaj   +1 more source