What Does the Shape Space of T Cell Epitopes Look Like? [PDF]
Buytenhuijs F, Schröder G, Textor J.
europepmc +1 more source
Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford +3 more
wiley +1 more source
Optimizing sustainable healthcare location routing problem: Incorporating triage, automated medicine lockers, and soft time windows. [PDF]
Samadi Bahrami Z +2 more
europepmc +1 more source
This work presents a magnetic‐bearing acoustic resonator that overcomes the thermodynamics limit of sound absorption. By introducing tunable negative stiffness, it achieves broadband low‐frequency absorption within a compact cavity, far exceeding the performance achievable by classic mass‐tuned designs.
Ying Hu +5 more
wiley +1 more source
A Hybrid Optimization Model for Shelter Location and Materials Assignment in Earthquakes Based on Evacuation Behavior. [PDF]
Geng S, Tang H.
europepmc +1 more source
scTIDE identifies single‐cell tipping points by combining manifold‐based graph representations with optimal‐transport conditional flow matching, which preserves intrinsic topology and models distributional dynamics. It supports critical‐transition detection at individual‐cell resolution, prediction of unseen cells, and dimensionality reduction and ...
Jiayuan Zhong +6 more
wiley +1 more source
A Quantum Annealing Approach for Solving Optimal Feature Selection and Next Release Problems. [PDF]
Zhang Y, Wang S, Yang W.
europepmc +1 more source
Gap‐Free Information Transfer in 4D‐STEM via Fusion of Complementary Scattering Channels
Fused Full‐Field STEM (FF‐STEM) is introduced as a 4D‐STEM imaging modality that combines direct ptychography with tilt‐corrected dark‐field reconstruction in a single acquisition. Fourier‐space fusion using Wiener‐type spectral weighting closes the low‐frequency contrast gap inherent to bright‐field methods, delivering gap‐free, dose‐efficient, near ...
Shengbo You +15 more
wiley +1 more source
Closing the Empirical Loop: Autonomous AI Agents Conduct End‐to‐end Research With Human Participants
A multi‐agent AI system autonomously executes the complete scientific workflow, from hypothesis to manuscript, across three psychological studies involving 288 participants. The system designs experiments, collects real world data, develops analysis pipelines, and writes manuscripts with theoretical rigor comparable to experienced researchers.
Gabrielle Wehr +6 more
wiley +1 more source
Long-Horizon Constraint-Aware Collaborative Scheduling for Multiple Phased-Array Radars Using Mamba Temporal Encoding and Structured Hybrid Actions. [PDF]
Liu J, Xu J, Xing W, Li M.
europepmc +1 more source

