Results 61 to 70 of about 1,197,135 (323)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Two-stage Kondo effect in a four-electron artificial atom

, 2005
An artificial atom with four electrons is driven through a singlet-triplet transition by varying the confining potential. In the triplet, a Kondo peak with a narrow dip at drain-source voltage V_ds=0 is observed. The low energy scale V_ds* characterizing
A. C. Gossard, G. Granger, Iuliana Radu, M. A. Kastner, M. P. Hanson, W. Hofstetter   +5 more
core   +1 more source

MapZ forms a stable ring structure that acts as a nano-track for FtsZ treadmilling in Streptococcus mutans

bioRxiv, 2017
Bacterial binary division requires the accurate placement of the division machinery. FtsZ, the vital component of the division machinery, can assemble into filaments and self-organize into a ring structure (Z-ring) at the proper site for cell division ...
Yongliang Li, S. Shao, Xiao Xu, X. Su, Yujie Sun, Shicheng Wei   +5 more
semanticscholar   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Biophysical model of the role of actin remodeling on dendritic spine morphology.

PLoS ONE, 2017
Dendritic spines are small membranous structures that protrude from the neuronal dendrite. Each spine contains a synaptic contact site that may connect its parent dendrite to the axons of neighboring neurons.
C A Miermans, R P T Kusters, C C Hoogenraad, C Storm   +3 more
doaj   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

FtsZ-Dependent Elongation of a Coccoid Bacterium

mBio, 2016
A mechanistic understanding of the determination and maintenance of the simplest bacterial cell shape, a sphere, remains elusive compared with that of more complex shapes.
Ana R. Pereira, Jen Hsin, Ewa Król, Andreia C. Tavares, Pierre Flores, Egbert Hoiczyk, Natalie Ng, Alex Dajkovic, Yves V. Brun, Michael S. VanNieuwenhze, Terry Roemer, Rut Carballido-Lopez, Dirk-Jan Scheffers, Kerwyn Casey Huang, Mariana G. Pinho   +14 more
doaj   +1 more source

Acquired Constriction Ring [PDF]

Pediatric Emergency Care, 2017
Abstract Rubber band syndrome is a rare entity seen in younger children mainly in communities where rubber bands are worn around the wrist for decorative purposes. When the band is worn for a long duration, it burrows through the skin and soft tissues resulting in distal edema, loss of function, and even damage to the neurovascular structures.
Meier, Rahel, Haug, Luzian Carlo Peter, Surke, Carsten, Mathys, Lukas, Vögelin, Esther   +4 more
openaire   +3 more sources

Robust gap repair in the contractile ring ensures timely completion of cytokinesis

bioRxiv, 2016
Cytokinesis in animal cells requires the constriction of an actomyosin contractile ring, whose architecture and mechanism remain poorly understood. We use laser microsurgery to explore the biophysical properties of constricting contractile rings in C ...
A. M. Silva, D. S. Osório, António J. Pereira, H. Maiato, I. M. Pinto, B. Rubinstein, R. Gassmann, I. A. Telley, A. Carvalho   +8 more
semanticscholar   +1 more source

Sex Hormones Associate With Amyotrophic Lateral Sclerosis Risk and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) risk differs by sex and age, implicating sex hormones as potential modifiers. This study examined plasma levels of biologically active sex hormones and their association with ALS odds and survival in cases (females n = 131, males n = 189) and controls (females n = 138, males n = 150) from the University of ...
Stephen A. Goutman, David G. Stouffer, Dae‐Gyu Jang, Jihyun Park, Benjamin J. Murdock, Richard J. Auchus   +5 more
wiley   +1 more source