Results 341 to 350 of about 294,955 (400)

P21‐Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy

Advanced Science, EarlyView.
Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li, Ting Liu, Yan Wang, Yangpeng Li, Leiying Liu, James Bae, Yu He, Xian Luo, Zhu Liu, Tangting Chen, Xianhong Ou, Dan Zhang, Huan Lan, Juyi Wan, Yan Wei, Fang Zhao, Xin Wang, Tao Li, Christopher L.‐H. Huang, Chunxiang Zhang, Ming Lei, Xiaoqiu Tan   +21 more
wiley   +1 more source

Task-evoked pupil responses during free-viewing of hierarchical figures in relation to autistic traits in adults. [PDF]

Sci Rep
Brittenham C, DiCriscio AS, Troiani V, Hu Y, Wagner JB.   +4 more
europepmc   +1 more source

A Knowledge‐Guided Graph Learning Approach Bridging Phenotype‐ and Target‐Based Drug Discovery

Advanced Science, EarlyView.
Knowledge‐Guided Drug Relational Predictor (KGDRP), a graph representation learning approach, effectively integrates multiple omics data, including biological network data, gene expression data, and sequence data that incorporates chemical molecular structures.
Qing Ye, Yundian Zeng, Linlong Jiang, Yu Kang, Peichen Pan, Jiming Chen, Yafeng Deng, Haitao Zhao, Shibo He, Tingjun Hou, Chang‐Yu Hsieh   +10 more
wiley   +1 more source

Investigating ocular biomarkers and differential diagnosis of Alzheimer's disease and vascular cognitive impairment based on multimodal imaging. [PDF]

J Biomed Opt
Jin Z, Chen X, Jiang C, Feng X, Shang K, Li J, Ren Q, Zhou C.   +7 more
europepmc   +1 more source

Low‐Irradiance Antimicrobial Blue Light‐Bathing Therapy for Wound Infection Control

Advanced Science, EarlyView.
Antimicrobial blue light has been shown as an appealing non‐pharmacological antimicrobial alternative. However, its clinical applications have been hindered by high irradiance‐associated photothermal risks. In this work, a low‐irradiance blue light‐bathing concept and a wearable photonic wound patch are established to address this challenge in terms of
Jie Hui, Wonjoon Moon, Pu‐Ting Dong, Carolina dos Anjos, Laisa Negri, Hao Yan, Ying Wang, Joshua Tam, Tianhong Dai, R. Rox Anderson, Jeremy Goverman, Jeffrey A. Gelfand, Seok‐Hyun Yun   +12 more
wiley   +1 more source

Three-dimensional printing-guided percutaneous transcatheter replacement in coarctation of the aorta: a retrospective study. [PDF]

Front Cardiovasc Med
He Q, Xu C, Liu Y, Jin P, Zhai M, Qiao R, Tian Z, Cui B, Yang J.   +8 more
europepmc   +1 more source

Multiple Interactions in Polar Lead‐Free Perovskites toward Highly Stable X‐Ray Detection

Advanced Science, EarlyView.
In this work, 0D polar lead‐free halide perovskites (R/S‐BPEA)4Bi2I10 (R/S‐BPEA = R/S‐1‐(4‐bromophenyl)ethylammonium) with multiple interactions are successfully constructed by introducing a chiral organic cation BPEA. The devices based on their high‐quality SC exhibit excellent self‐driven X‐ray detection performance and high operational stability ...
Chang Qu, Jianbo Wu, Zeng‐kui Zhu, Qianwen Guan, Huang Ye, Ruiqing Li, Chengshu Zhang, Yaru Geng, Hang Li, Lijun Xu, Haiqing Zhong, Ailin Wang, Chengmin Ji, Zhenyue Wu, Junhua Luo   +14 more
wiley   +1 more source

Pupillary responses to bright and dark stimuli in individuals with autism spectrum disorders. [PDF]

PLoS One
Hayakawa T, Nakano S, Inada N, Saneyoshi A, Tsujita M, Kumagaya S, Hara N.   +6 more
europepmc   +1 more source

Advancing Allogeneic NK Cell Immunotherapy through Microfluidic Gene Delivery

Advanced Science, EarlyView.
The Y‐Hydroporator is a microfluidic gene delivery platform designed for allogeneic NK cell‐based immunotherapies. It achieves highly efficient gene delivery while preserving high cell viability and functionality. By producing engineered NK cells with enhanced cytotoxicity, the platform addresses critical limitations of autologous cell therapy ...
Hyelee Kim, Mujin Lee, Bohwa Han, Jinho Kim, Duck Cho, Junsang Doh, Aram J. Chung   +6 more
wiley   +1 more source

Left atrial reservoir strain as a predictor of cardiac dysfunction in a murine model of pressure overload. [PDF]

Acta Physiol (Oxf)
Salvas JP, Moore-Morris T, Goergen CJ, Sicard P.   +3 more
europepmc   +1 more source