Results 71 to 80 of about 11,231 (193)

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Surgical management of constrictive pericarditis [PDF]

, 2010
Background: Constrictive pericarditis is a disease characterized by marked thickening and dense scarring of the pericardium with pericardial sac obliteration, or calcification of the pericardium.
Kotei, D, Frimpong-boateng, K, Tettey, m, Aniteye, E, Sereboe, L, Edwin, F, Tamatey, M, Entsuamensah, K   +7 more
core   +1 more source

Constrictive Pericarditis Treated by Surgery [PDF]

, 2012
We reviewed the records of 45 patients (mean age, 46.6 ± 14.9 yr; range, 21–84 yr) with a diagnosis of constrictive pericarditis who had undergone pericardiectomy from 1994 through 2006.
Ghavidel, Alireza A, Kyavar, Majid, Tabatabaie, Mohammad-Bagher, Mirmesdagh, Yalda, Gholampour, Maziar   +4 more
core   +1 more source

The Effects of Angiotensin Receptor Neprilysin Inhibitor on Endoplasmic Reticulum Stress in Doxorubicin‐Mediated Cardiomyopathy‐Associated Heart Failure Model in Rats

Journal of Applied Toxicology, EarlyView.
ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan, Meryem İlkay Karagül, Hatice Oruç Demirbağ, Ebru Balli   +3 more
wiley   +1 more source

Predictors of postoperative complication and prolonged intensive care unit stay after complete pericardiectomy in tuberculous constrictive pericarditis

Journal of Cardiothoracic Surgery, 2020
Background The risk factors of postoperative outcomes after pericardiectomy in tuberculous constrictive pericarditis have still been unclear. This study aimed to investigate the predictors of postoperative complication and prolonged intensive care unit ...
Likui Fang, Guocan Yu, Jinpeng Huang, Wuchen Zhao, Bo Ye   +4 more
doaj   +1 more source

Normal tissue complication probability models of late cardiopulmonary toxicity following deep inspiration breath hold for breast cancer adjuvant radiotherapy

Precision Radiation Oncology, EarlyView.
Deep inspiration breath hold (DIBH) markedly cuts heart and left lung radiation doses during left‐sided breast cancer radiotherapy. The normal tissue complication probability (NTCP) model further confirms lower predicted cardiopulmonary toxicities versus free breathing (FB), potentially improving patients’ quality of life.
Lin Lin, Liang Liu, Zhengxin Gao, Yaling Hong, Qing Gong, Zhan Yu, Xue Liu, Qiaoying Hu, Yongqiang Li, Shen Fu, Qi Yu   +10 more
wiley   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Quantification of echodensities in tuberculous pericardial effusion using fractal geometry: a proof of concept study

Cardiovascular Ultrasound, 2012
Background The purpose of this study was to quantify the heterogeneous distribution of echodensities in the pericardial fluid of patients with tuberculous pericarditis using echocardiography and fractal analysis, and to determine whether there were ...
Ntsekhe Mpiko, Mayosi Bongani M, Gumbo Tawanda   +2 more
doaj   +1 more source

Case series: Kikuchi‐Fujimoto disease with diagnostic overlap

Rheumatology &Autoimmunity, EarlyView.
Kikuchi‐Fujimoto disease (KFD) is a rare, self‐limiting necrotizing lymphadenitis that poses significant diagnostic challenges due to its overlap with tuberculosis, systemic lupus erythematosus (SLE), and malignancy. We present four cases highlighting distinct diagnostic complexities: KFD mimicking tuberculosis with concomitant latent TB infection and ...
Ecem Kalemoglu, Ming Zheng, Danny Arias, Andreina M. Paulino, Aisha Niaz, James Devlin, Valentin Marian   +6 more
wiley   +1 more source

Rituximab and pericardiectomy with waffle procedure in constrictive pericarditis due to IgG4‐related disease: A case report

Clinical Case Reports
Key Clinical Message We should consider IgG4‐related disease (IGRD) as one of the potential causes of constrictive pericarditis. In patients with constrictive pericarditis due to IGRD, the combination of surgical treatment and immunosuppressive therapy ...
Toshitaka Okabe, Taishi Kawahata, Yui Koyanagi, Yuki Ito, Yuma Gibo, Takeshi Okura, Naoei Isomura, Akihiro Nabuchi, Hiroshi Okuyama, Masahiko Ochiai   +9 more
doaj   +1 more source