Results 151 to 160 of about 416,163 (244)

Nanocrystal Compressive Residual Stresses: A Strategy to Strengthen the Bony Spines of Osteocytic and Anosteocytic Fish

Advanced Science, EarlyView.
Advanced neoteleost fishbones, such as medaka, challenge bone adaptation strategies. While zebrafish bones contain osteocyte‐mediated porosity, medaka bones lack it, raising questions about alternative reinforcement mechanisms. Using advanced imaging, this study reveals higher residual compressive strains in medaka bone, suggesting an adaptation that ...
Andreia Silveira, Anton Davydok, Christina Krywka, Mario Scheel, Timm Weitkamp, Claudia Fleck, Ron Shahar, Paul Zaslansky   +7 more
wiley   +1 more source

Large‐Area Conductor‐Loaded PDMS Flexible Composites for Wireless and Chipless Electromagnetic Multiplexed Temperature Sensors

Advanced Science, EarlyView.
This work demonstrates the first chipless temperature sensing array based on conductor‐loaded composites. They allow multiple items to be simultaneously identified and monitored through multiplexed electromagnetic reflections. The work studies the influence of conductive fillers on the frequency‐domain properties of PDMS, for the first time.
Benjamin King, Nikolas Bruce, Mahmoud Wagih   +2 more
wiley   +1 more source

The Super Enhancer‐Driven Long Noncoding RNA PRKCQ‐AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds

Advanced Science, EarlyView.
PRKCQ‐AS1 is overexpressed due to transcriptional super‐enhancers. PRKCQ‐AS1 RNA forms a complex with MSI2 protein to induce BMX mRNA stabilization and overexpression, ERK protein phosphorylation and neuroblastoma cell proliferation. Compound NSC617570 blocks PRKCQ‐AS1 binding to MSI2, leading to BMX mRNA disassociation from MSI2 protein, BMX reduction,
Sujanna Mondal, Pei Y. Liu, Janith Seneviratne, Antoine De Weck, Pooja Venkat, Chelsea Mayoh, Jing Wu, Jesper Maag, Jingwei Chen, Matthew Wong, Nenad Bartonicek, Poh Khoo, Lei Jin, Louise E. Ludlow, David S. Ziegler, Toby Trahair, Pieter Mestdagh, Belamy B. Cheung, Jinyan Li, Marcel E. Dinger, Ian Street, Xu D. Zhang, Glenn M. Marshall, Tao Liu   +23 more
wiley   +1 more source

Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea

Advanced Science, EarlyView.
This study indicates that Serpine2 plays a pivotal role in hair cell (HC) regeneration from Lgr5+ progenitors in the neonatal mouse cochlea. Conditional overexpression of Serpine2 in cochlear Lgr5+ progenitors results in a significantly increased number of ectopic HCs, particularly ectopic inner HCs, and these HCs are likely derived from Lgr5 ...
Hairong Xiao, Jiheng Wu, Lixuan Huang, Ying Ma, Leilei Wu, Yanqin Lin, Zixuan Ye, Xin Tan, Xujun Tang, Wei Tong, Mingchen Dai, Yintao Wang, Xia Sheng, Renjie Chai, Shasha Zhang   +14 more
wiley   +1 more source

A computational framework for extracting biological insights from SRA cancer data. [PDF]

Sci Rep
Guimarães PAS, Carvalho MGR, Ruiz JC.
europepmc   +1 more source

Unwrapping the Ciliary Coat: High‐Resolution Structure and Function of the Ciliary Glycocalyx

Advanced Science, EarlyView.
The ciliary membrane is decorated in glycosylated proteins that define the interaction of the cilium with its environment. The main component of the ciliary coat of the green alga Chlamydomonas reinhardtii, FMG1, is characterized by cryo‐electron microscopy, proteomics, and live cell microscopy with flow‐based adhesion assays.
Lara M. Hoepfner, Adrian P. Nievergelt, Fabrizio Matrino, Martin Scholz, Helen E. Foster, Jonathan Rodenfels, Alexander von Appen, Michael Hippler, Gaia Pigino   +8 more
wiley   +1 more source

NeuroCarto: A Toolkit for Building Custom Read-out Channel Maps for High Electrode-count Neural Probes. [PDF]

Neuroinformatics
Su TS, Kloosterman F.
europepmc   +1 more source

4D Biofabrication of Magnetically Augmented Callus Assembloid Implants Enables Rapid Endochondral Ossification via Activation of Mechanosensitive Pathways

Advanced Science, EarlyView.
Magnetically augmented biohybrid cartilaginous microtissues enable remote microtissue motion control and assembly as well as targeted differentiation. This study demonstrates accelerated endochondral ossification under magnetic stimulation, highlighting cartilaginous assembloid constructs’ ability to retain long‐term magnetic properties.
Konstantinos Ioannidis, Andreas Dimopoulos, Isaak Decoene, Maya Guilliams, Hanna Svitina, Liudmyla Storozhuk, Rodrigo de Oliveira‐Silva, Sergey Basov, Nguyen Thi Kim Thanh, Stefanos Mourdikoudis, Margriet J. Van Bael, Bart Smeets, Dimitrios Sakellariou, Ioannis Papantoniou   +13 more
wiley   +1 more source

User guide for Social Determinants of Health Survey data in the All of Us Research Program. [PDF]

J Am Med Inform Assoc
Koleck TA, Dreisbach C, Zhang C, Grayson S, Lor M, Deng Z, Conway A, Higgins PDR, Bakken S.   +8 more
europepmc   +1 more source

Using Large Language Model to Optimize Protein Purification: Insights from Protein Structure Literature Associated with Protein Data Bank

Advanced Science, EarlyView.
An automated tool incorporating a large language model (LLM) streamlines the extraction and classification of protein expression and purification methods from 64 909 PDB‐associated articles. By identifying trends in buffer components, fusion tags, expression conditions, and crosslinker/detergent preferences, the tool provides valuable insights into the
Zhuojian Chen, J. Sivaraman
wiley   +1 more source