Results 161 to 170 of about 25,556 (192)

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source

SpatialRNA: a Python package for easy application of Graph Neural Network models on single-molecule spatial transcriptomics dataset. [PDF]

Bioinformatics
Lyu R, Vannan A, Kropski JA, Banovich NE, McCarthy DJ.   +4 more
europepmc   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Martinize2 and Vermouth provide a unified framework for molecular topology generation. [PDF]

Elife
Kroon PC, Grünewald F, Barnoud J, van Tilburg M, Brasnett C, Souza PCT, Wassenaar TA, Marrink SJ.   +7 more
europepmc   +1 more source

Quantitative Stain Mapping in X‐Ray Virtual Histology

Advanced Science, EarlyView.
Virtual histology promises 3D tissue examination without physical sectioning, yet has lacked the tissue‐specificity of conventional pathology. This work demonstrates the first quantitative three‐dimensional stain mapping at histologically relevant resolution, separating contrast agent from tissue to reveal cellular features such as nuclei. The approach
Dominik John, David M. Paganin, Marie‐Christine Zdora, Lisa Marie Petzold, Patrick Ilg, Junan Chen, Sara Baggio, Johannes B. Thalhammer, Sami Wirtensohn, Julian Moosmann, Jörg U. Hammel, Felix Beckmann, Samantha J. Alloo, Jannis N. Ahlers, Madleen Busse, Julia Herzen, Kaye S. Morgan   +16 more
wiley   +1 more source

MyESL: A Software for Evolutionary Sparse Learning in Molecular Phylogenetics and Genomics. [PDF]

Mol Biol Evol
Sanderford M, Sharma S, Stecher G, Suleski M, Liu J, Ye J, Kumar S.   +6 more
europepmc   +1 more source

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

Advanced Science, EarlyView.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He, Yunpei Xu, Liqing Ding, Hong‐Dong Li, Yaohang Li, Shaokai Wang   +5 more
wiley   +1 more source

AFragmenter: schema-free, tuneable protein domain segmentation for AlphaFold protein structures. [PDF]

Bioinformatics
Verwimp S, Lavigne R, Lood C, van Noort V.   +3 more
europepmc   +1 more source

SmartBuildSim: An Open-Source Synthetic-Twin Framework for Reproducible AI Benchmarking in Smart-Building Analytics. [PDF]

Sensors (Basel)
Miller T, Durlik I, Nowy A, Kostecka E.
europepmc   +1 more source

A versatile platform for combinatorial antibody library cloning and NGS-based quality control with high accuracy. [PDF]

Nucleic Acids Res
Zhang Z, D'Hondt S, Van der Kant R, Hermans G, Geukens N, Pinheiro VB, Schymkowitz J, Rousseau F, Dewilde M.   +8 more
europepmc   +1 more source