Results 41 to 50 of about 42,703 (300)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Dynamics of interacting populations language contact in the Lwoo languages of Bahr el-Ghazal

open access: yesStudies in African Linguistics, 2003
Number inflection systems in Western Nilotic languages appear highly complex and diverse. Comparative work on Nilotic and other Nilo-Saharan families has shown that these languages have a morphologically tripartite system with marked plurals and a bare ...
Anne Storch
doaj   +3 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

LANGUAGE AS A TOOL OF INFLUENCE: A DISCOURSE ANALYSIS OF DAENERYS TARGARYEN’S SPEECHES IN DOTHRAKI AND HIGH VALYRIAN IN GAME OF THRONES

open access: yesStudia Universitatis Babeş-Bolyai. Philologia
Language as a Tool of Influence: Discourse Analysis of Daenerys Targaryen’s Speeches in Dothraki and High Valyrian in Game of Thrones. This article delves into the examination of the multilingual discourse and diplomatic strategies employed by Daenerys ...
Bettina ENE
doaj   +1 more source

The digital fandom of Na'vi speakers

open access: yesTransformative Works and Cultures, 2015
Few academic studies have focused on the fans of created or constructed languages. One reason behind this may be the popular impression, intensified by the media, that speakers of these languages are obsessed fans or fanatics.
Christine Schreyer
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Constructed Languages of Hildegard of Bingen and Suzzette Haden Elgin. Female Empowerment through Language?

open access: yes, 2018
Since constructed languages have recently been brought into focus by their prominent presence in film and television production, they have also become more attractive for academic research: several compendia, monographs, and articles have been published ...
Skowrońska, Dorota
core   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

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