In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková+14 more
wiley +1 more source
The effect of water boundary conditions of advance face and lining on the evolution of internal forces in lining [PDF]
Feng, S.+5 more
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Visualisation of semantic architectural information within a game engine environment [PDF]
Because of the importance of graphics and information within the domain of architecture, engineering and construction (AEC), an appropriate combination of visualisation technology and information management technology is of utter importance in the ...
De Meyer, Ronald+2 more
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The US Army Construction Engineering Research Laboratory [PDF]
Enka Istanboul
openalex +1 more source
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim+11 more
wiley +1 more source
Systems engineering studies of lunar base construction [PDF]
Many ingenious concepts have been proposed for lunar base construction, but few systematic studies exist which relate time-consistent lunar base construction technologies and the choice of lunar base approach with the long-term SEI objectives - i.e ...
Morgenthaler, George W.
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Elements of mechanism: elucidating the scientific principles of the practical construction of machines, for the use of schools, and students in mechanical engineering, with numerous specimens of modern machines, remarkable for their utility and ingenuity [PDF]
T. Baker, James Arthur
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Practical Guide to Engineering and Construction Contracts
Book ReviewPractical Guide to Engineering and Construction Contracts Philip Loots and Donald Charrett, CCH Australia Limited, Sydney 2009, 439 pages plus index, ISBN 9781921593529 (hardback) AUD ...
openaire +6 more sources
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez+5 more
wiley +1 more source
SASICE: Safety and sustainability in civil engineering
The performance of the built environment and the construction sector are of major importance in Europe’s long term goals of sustainable development in a changing climate. At the same time, the quality of life of all European citizens needs to be improved
Azevedo, J+10 more
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