Results 21 to 30 of about 585,516 (192)
FEBS Letters, EarlyView.We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin +2 more
wiley +1 more source
RPSE: Reification as Paradigm of Software Engineering [PDF]
arXiv, 2018 The paper introduces RPSE, Reification as a Paradigm of Software Engineering, and enumerates the most important theoretical and practical problems of the development and application of this paradigm. Main thesis: Software engineering is the reification (materialization of ideas) via the transformation of mental models into code executed on computers ...
arxiv
Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones
FEBS Letters, EarlyView.Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley +1 more source
Chersiphron & Son Engineers [PDF]
arXiv, 2011 An ancient engineering firm worked successfully in the construction of one of the Seven Wonders of the Ancient World. The engineers used inclined planes, bags of sand and shafts of columns and architraves as wheels and axels.
arxiv
FEBS Letters, EarlyView.This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause +2 more
wiley +1 more source
Electromagnetically Induced Transparency and Quantum Heat Engines [PDF]
, 2016 We describe how electromagnetically induced transparency may be used to construct a non-traditional near-ideal quantum heat engine as constrained by the Second Law. The engine is pumped by a thermal reservoir that may be either hotter or colder than that of an exhaust reservoir, and also by a monochromatic laser.
arxiv +1 more source
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
FEBS Letters, EarlyView.The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva +1 more
wiley +1 more source
The smallest possible heat engines [PDF]
arXiv, 2010 We construct the smallest possible self contained heat engines; one composed of only two qubits, the other of only a single qutrit. The engines are self-contained as they do not require external sources of work and/or control. They are able to produce work which is used to continuously lift a weight.
arxiv
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source