Results 41 to 50 of about 748,631 (270)

Improving the Reporting of Threats to Construct Validity [PDF]

arXiv, 2023
Background: Construct validity concerns the use of indicators to measure a concept that is not directly measurable. Aim: This study intends to identify, categorize, assess and quantify discussions of threats to construct validity in empirical software engineering literature and use the findings to suggest ways to improve the reporting of construct ...
arxiv  

Entangled quantum Otto heat engines based on two-spin systems with the Dzyaloshinski-Moriya interaction [PDF]

Quantum Inf Process (2017) 16:216, 2017
We construct an entangled quantum Otto engine based on spin-1/2 systems undergoing Dzyaloshinski-Moriya (DM) interaction within a varying magnetic field. We investigate the influence of the DM interaction on basic thermodynamic quantities, including heat transfer, work done, and efficiency and find that the DM interaction importantly influences the ...
arxiv   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Efficient Quantum Measurement Engine [PDF]

Phys. Rev. Lett. 120, 260601 (2018), 2018
We propose quantum engines powered entirely by the quantum measurement process. Our theoretical construction of the engine requires no work from the system Hamiltonian, and takes energy only from the process of observation to move a particle against a force.
arxiv   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Forecasting Future Research Trends in the Construction Engineering and Management Domain Using Machine Learning and Social Network Analysis

Modelling
Construction Engineering and Management (CEM) is a broad domain with publications covering interrelated subdisciplines and considered a key source of knowledge sharing.
Gasser G. Ali, Islam H. El-adaway, Muaz O. Ahmed, Radwa Eissa, Mohamad Abdul Nabi, Tamima Elbashbishy, Ramy Khalef   +6 more
doaj   +1 more source

Automatic detection method of abnormal vibration of engineering electric drive construction machinery

Electronic Research Archive, 2023
Aiming at the problem that the extraction effect of abnormal vibration characteristics of current engineering electric drive construction machinery is poor, an automatic detection method of abnormal vibration of engineering electric drive construction ...
Jian Yuan , Hao Liu, Yang Zhang
doaj   +1 more source