Results 51 to 60 of about 2,280,486 (356)

occumb: An R package for site occupancy modeling of eDNA metabarcoding data

Population Ecology, EarlyView.
This study introduces a new R package, occumb, for the convenient application of site occupancy modeling using environmental DNA (eDNA) metabarcoding data. We outline a data analysis workflow, including data setup, model fitting, model assessment, and comparison of potential study settings based on model predictions, all of which can be performed using
Keiichi Fukaya, Yuta Hasebe
wiley   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Looking back to see the future: building nuclear power plants in Europe [PDF]

, 2011
The so-called ‘nuclear renaissance’ in Europe is promulgated by the execution of two large engineering projects involving the construction of two European Pressurized Reactors (EPRs) in Flamanville, France and Olkiluoto in Finland.
Flyvbjerg B., Flyvbjerg B., Giorgio Locatelli, Hecht G., Lovallo D., Mauro Mancini, Miller R., Miller R., Quinet E., Rezgui Y., Wachs M., Yin R.K.   +11 more
core   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Public Perceptions of the Midwest’s Pavements - Minnesota - Phase I (Winter Ride) [PDF]

, 1997
The Minnesota Winter Ride Survey was designed to gauge the extent to which motorists were tolerant of the rougher ride of pavements on rural two-lane highways in the winter. Survey objectives, therefore, were centered around this focal question of winter
Marquette University, Department of Civil, Construction, and Environmental Engineering, University of Wisconsin - Extension, Wisconsin Survey Research Laboratory   +1 more
core   +1 more source

A contribution to the lexis of construction engineering textbooks

Ibérica, 2008
The integration of a genre-based and a corpus-based instruction in ESP learning (Swales, 1990; Tribble, 2000; Ferguson, 2001; Flowerdew, 2005) has proved to be a suitable theoretical framework for describing the lexis of construction and architecture ...
Concepción Orna Montesinos
doaj  

Development of multilayer constructs for tissue engineering [PDF]

Journal of Tissue Engineering and Regenerative Medicine, 2012
The rapidly developing field of tissue engineering produces living substitutes that restore, maintain or improve the function of tissues or organs. In contrast to standard therapies, the engineered products become integrated within the patient, affording a potentially permanent and specific cure of the disease, injury or impairment.
N.M.S. Bettahalli, Dimitrios Stamatialis, Nathalie Groen, J. de Boer, Matthias Wessling, Hilde Steg, H.V. Unadkat, C.A. van Blitterswijk   +7 more
openaire   +3 more sources

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source