Results 61 to 70 of about 2,428,776 (309)

Information technology in construction: How to realise the benefits? [PDF]

, 2003
Advancement in the utilisation of computers has, in recent years, become a major, even dominating research and development target in the architecture, engineering and construction industry.
Kazi, AS, Koskela, LJ
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Forecasting Future Research Trends in the Construction Engineering and Management Domain Using Machine Learning and Social Network Analysis

Modelling
Construction Engineering and Management (CEM) is a broad domain with publications covering interrelated subdisciplines and considered a key source of knowledge sharing.
Gasser G. Ali, Islam H. El-adaway, Muaz O. Ahmed, Radwa Eissa, Mohamad Abdul Nabi, Tamima Elbashbishy, Ramy Khalef   +6 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Report of the Section of the Committee for Civil Engineering in the Term 2007–2010 / Sekcja Inzynierii Przedsiewziec Budowlanych W Kadencji 2007 – 2010. Raport

Archives of Civil Engineering, 2011
Streszczenie: Artykuł jest raportem charakteryzujacym srodowisko zajmujace sie technologia, organizacja i ekonomika budownictwa - głównie srodowisko akademickie zgrupowanego wokół Sekcji Inzynierii Przedsiewziec Budowlanych KILiW PAN.
Kapliński O
doaj   +1 more source

A three-dimensional intelligent engineering management and control system for the construction of a long-span valve hall project based on a microservice architecture.

PLoS ONE, 2021
Three-dimensional intelligent engineering management and control systems (EMCS) based on the browser/server (B/S) model are an important part of intelligent engineering development.
Qinghe Zeng, WeiHua Ming, Jin Luo, SongAn Zhang, Wei Hu, Zhen Liu, CuiYing Zhou   +6 more
doaj   +1 more source

Methodological Flaws in Cognitive Animat Research [PDF]

, 2009
In the field of convergence between research in autonomous machine construction and biological systems understanding it is usually argued that building robots for research on auton- omy by replicating extant animals is a valuable strategy for engineering
Gomez, Jaime, Hernández, Carlos, Sanchez, Guadalupe, Sanz, Ricardo   +3 more
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source