Results 121 to 130 of about 3,079,502 (307)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
The Application and Effects of Aerogel in Ultra-Lightweight Mineralised Foams
BuildingsThis study aims to explore the potential of aerogel to optimise the thermal conductivity of mineralised foam materials. Experiments were conducted with (i) addition methods of aerogel, (ii) proportion of aerogels in cement slurry, and (iii) water/cement ...
Tongyu Xu +3 more
doaj +1 more source
Development and mechanical properties of construction materials from lunar simulants [PDF]
The development of construction materials such as concrete from lunar soils without the use of water requires a different methodology than that used for conventional terrestrial concrete. Currently, this research involves two aspects: (1) liquefaction of
Desai, Chandra S.
core +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Theoretical model of effective elastic moduli of composites considering the inclusion features
Materials & DesignQuantifying the effect of composition on the two-phase composite’s mechanical properties is crucial for the life prediction and durability design of the whole structure.
Xuqian Liu, Zhangyu Wu, Shuohui Chen
doaj +1 more source
Normansfield theatre scenery: materials and construction revealed through conservation [PDF]
, 2013 Described as one of the finest collections of stock scenery in the country, and a rare survival from the 19th century, the painted scenery from Normansfield Theatre is the focus of this paper. A team of conservators from the Textile Conservation Centre,
Lennard, Frances, Thompson, Karen
core
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Development of durable “green” concrete exposed to deicing chemicals via synergistic use of locally available recycled materials and multi-scale modifiers [PDF]
, 2018 From the economic and social perspectives, the use of waste materials would not be attractive until their costs and quality can satisfy the construction requirements.
Cui, Na, Xie, Ning
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Results in EngineeringThe utilization of tunnel slag as concrete aggregate is an effective means of achieving resource recycling. This study employs a mesoscopic numerical simulation method to investigate the dynamic mechanical properties of concrete incorporating tunnel slag
Taotao Feng +3 more
doaj +1 more source