Results 161 to 170 of about 13,767,907 (348)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Role of Material Structure in Compacted Earthen Building Materials: Implications for Design and Construction [PDF]

, 2011
Rammed earth is an earthen construction material and an ancient construction technique. It is formed by compacting layers of moist sandy loam subsoil into formwork which is then removed, exposing the material and creating a freestanding, monolithic ...
BECKETT, CHRISTOPHER,THOMAS,STONE, Beckett, Christopher Thomas Stone   +1 more
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Options in the selection of materials for basement construction

, 2008
Selection of proper materials is essential to the construction of basements that will provide liveable and comfortable indoor space. This Update discusses some of the key materials issues in basement construction and reviews the options regarding ...
Swinton, M. C., Kesik, T. J.
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Towards Understanding Aerogels' Effect on Construction Materials: A Principal Component Analysis Approach. [PDF]

Gels, 2023
Obeid E, Chaouk H, Mezher R, Gazo Hanna E, Mouhtady O, Halwani J, Younes K.   +6 more
europepmc   +1 more source

Conversion of waste into sustainable construction materials: A review of recent developments and prospects

Materials Today Sustainability
Lin Chen, Mingyu Yang, Zhonghao Chen, Zhuolin Xie, Lepeng Huang, Ahmed I. Osman, Mohamed Farghali, M. Sandanayake, Engui Liu, Y. Ahn, A. Al-Muhtaseb, David W. Rooney, P. Yap   +12 more
semanticscholar   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A knowledge-based decision support system for roofing materials selection

, 2009
Varieties of materials are available for roof housing construction but selecting the appropriate material is a complex and ponderous task. In order to choose the right material, a multitude of performance criteria would need to be considered.
Rahman, Sazzadur, Rahman, Sazzadur M., Perera, Srinath (R18622), Perera, Srinath, Bi, Yaxin, Odeyinka, Henry   +5 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source