Results 91 to 100 of about 14,503,149 (250)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
School storm shelter study report : to the 133rd Ohio General Assembly
, 2019 "December 2019."; Includes bibliographical referencesIntroduction -- Consultation with stakeholders -- Building code requirements for school storm shelters -- Storm shelter cost impact on OFCC projects -- 2018 moratorium -- 2019 moratorium and study ...
Ohio Facilities Construction Commission
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Peningkatan Produktivitas Konstruksi Melalui Pemilihan Metode Konstruksi
Dinamika Rekayasa, 2012 Productivity growth in the construction is lower than that of in the industry sector. Level of innovation in this sector is too low. Many problems of inefficiency in the construction process are a lotof waste of resources that do not produce value ...
Paulus Setyo Nugroho
doaj
BuildingsThis article documents the rammed earth construction practices undertaken at the “Tiles Hill–Xiangshan Campus Reception Centre” project. Traditional rammed earth craftsmanship is a sustainable construction method, with its core rooted in the precise ...
Lichao Chen +7 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Report : enabling team collaboration with pervasive and mobile computing : cost benefit analysis methodology [PDF]
, 2006 Construction is an information intensive industry in which the accuracy and\ud timeliness of information is paramount. It observed that the main\ud communication issue in construction is to provide a method to exchange\ud data between the site operation,
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