Results 51 to 60 of about 14,503,149 (250)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Peran Kontraktor dalam Peningkatan Constructability pada Pembangunan Jalan Jembatan Wilayah Kalimantan Timur

Media Komunikasi Teknik Sipil, 2014
Contructability has been defined as the optimus usefull of construction knowledgeand experience in planning design, procurement and field operation to achieve overall can be effective, efficiency efficiency and good quality (CII, Uaustin, USA ...
Hendrik Sulistio, Magawaty Magawaty
doaj   +1 more source

Temporal pyramid construction method based on SRU [PDF]

Jisuanji gongcheng, 2019
Existing feature extraction methods based on temporal pyramid cannot learn the time dependence between video frames and video segments and the hierarchical structure information of video temporal is not fully utilized,resulting in insufficient video ...
ZHI Hongxin,YU Hongtao,LI Shaomei,GAO Chao
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Construction process categorisation towards developing an E-business maturity model [PDF]

, 2014
The rapid pace of change in technology coupled with global economic and environmental changes has had considerable impact on all business sectors. Consequently, organisations are forced to drive towards efficiency savings, productivity improvements and ...
Zhou, Lei, Perera, Srinath (R18622), Rodrigo, Anushi, Perera, Srinath, Udeaja, Chika   +4 more
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Development and Preliminary Application of PermanentForm of Ultra-high Performance Concrete

Renmin Zhujiang, 2020
Because ultra-high performance concrete (UHPC) has ultra-high strength and ultra-highdurability, it is a possible way for covering the outer surface of the reinforced concretestructure with UHPC permanent form to effectively improve the service life of ...
WANG Yongjian, LIU Fucai, YANG Yibo, XIE Xiangming, YAO Chukang, XIAO Min, GUO Wenying, WANG Hengchang   +7 more
doaj  

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source