Results 81 to 90 of about 166,792,772 (228)

Evolutionary logic and operational mechanism of digital governance in rural tourism: A case study of Jiebang Village in Shanghai and Wusi Village in Zhejiang [PDF]

open access: yesZiyuan Kexue
[Objective] In the process of rural revitalization and digital village construction, digital technologies are profoundly reshaping rural tourism governance, serving as a key driver in promoting the transformation of grassroots social governance and the ...
LIU Yixue, ZHOU Xiaohui, ZHANG Jinhe
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Experimental Investigation of Infrared Detection of Debonding in Concrete-Filled Steel Tubes via Cooling-Based Excitation

open access: yesBuildings
Debonding in concrete-filled steel tubes (CFSTs) is a common defect that often occurs during the construction phase of CFST structures, significantly reducing their load-bearing capacity.
Haonan Cai, Chongsheng Cheng
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Critical Appraisal of Coal Gangue and Activated Coal Gangue for Sustainable Engineering Applications

open access: yesApplied Sciences
Coal gangue, a primary solid waste by-product of coal mining and processing, constitutes approximately 10–15% of total coal output. Its accumulation poses substantial environmental challenges, including land occupation, spontaneous combustion, acid mine ...
Narlagiri Snehasree   +2 more
doaj   +1 more source

Synaptic behaviors of electromigrated Au nanogaps

open access: yesAIP Advances, 2019
Artificial electronic synapses or synaptic devices, which are capable of mimicking the functions of biological synapses in the human brain, are considered the basic building blocks for brain-inspired computing. Therefore, we investigated the emulation of
Keita Sakai   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Highly stable dual-carbon conductive TPU composites for intelligent strain sensing: experiments and molecular simulation

open access: yese-Polymers
Soft interlayered rock slopes with gently dipping bedding planes are highly susceptible to deformation accumulation, local strain concentration, and instability during dynamic excavation and construction.
Li Lidan, Zhou Jianying, Li Cheng
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Final report : task 4 : waste minimisation in construction [PDF]

open access: yes, 2005
The Regenerating Construction Project for the CRC for Construction Innovation aims to\ud assist in the delivery of demonstrably superior ‘green’ buildings.

core  

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