Results 51 to 60 of about 1,003,808 (216)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Time and Cost Overrun in Construction Projects of Pakistan
Pakistan Journal of Engineering & Technology, 2019 According to this research, time and cost overruns in construction initiatives of Pakistan. So, carried out the qualitative questionnaire survey to collect the data for each time and cost invades.
Asad Iqbal +10 more
doaj +3 more sources
Modeling of the Time Structure of Construction Processes Using Neural Networks
Organization, Technology and Management in Construction: An International Journal, 2017 The aim of this research is to develop a methodology for calculating the standard time using neural networks. The paper presents research questions and proposes a methodology.
Petlíková Kateřina, Jarský Čeněk
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Waste Cooking Oil-Modified Epoxy Asphalt Rubber Binders with Improved Compatibility and Extended Allowable Construction Time. [PDF]
Molecules, 2022 Gong J +6 more
europepmc +1 more source
Construction: Notes on Qualitative Time and Space
Pensamiento. Revista de Investigación e Información Filosófica, 2015 The conceptual definition of time and space has given rise to some difficulties in classical philosophy. These difficulties worsen with reference to time, which is presented as an «obscure idea». The root of the problem lies in considering time and space
José Antón Pacheco
doaj
Simulation of virtual time norms for technological processes
Journal of Business Economics and Management, 2003 The methodology presented in the article is based on the simulation of technological process duration, restricting on the available information about total duration of complex technological process in the conditions when there are no possibilities to ...
Romualdas Tamošaitis +1 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source