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Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma+9 more
wiley +1 more source
Reforming the contract of UK consultants [PDF]
The NHS Plan expressed the intention of government to "fundamentally overhaul" the national contract for UK hospital specialists to "reward and incentivise those who do most for the NHS." How can this be ...
Bloor, K, Maynard, A
core +1 more source
CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki+2 more
wiley +1 more source
The aim of our study was to compare the performance of residents vs. consultants in transrectal fusion prostate biopsies (FUS-PBs), as well as patient-reported comfort.
Beatrice Turchi+11 more
doaj +1 more source
A Role-specific Guided Large Language Model for Ophthalmic Consultation Based on Stylistic Differentiation [PDF]
Ophthalmology consultations are crucial for diagnosing, treating, and preventing eye diseases. However, the growing demand for consultations exceeds the availability of ophthalmologists. By leveraging large pre-trained language models, we can design effective dialogues for specific scenarios, aiding in consultations.
arxiv
Stakeholder consultations are a key mechanism used by bureaucratic and legislative decision-makers to actively engage citizens and interest groups in the design, formulation and evaluation of public policies and legislation. Consultations allow policymakers to gather expertise and policy-relevant information about the feasibility of policy options, to ...
openaire +2 more sources
Co‐crystallization crystallizes a protein with its ligand, resulting in protein–ligand complex crystals. In contrast, soaking introduces a ligand into preformed protein crystals, allowing it to bind. Both methods produce crystals for X‐ray diffraction, which generates diffraction patterns that are analyzed to determine the three‐dimensional structure ...
Barbora Kaščáková+4 more
wiley +1 more source