Results 71 to 80 of about 808,049 (434)

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

open access: yesMolecular Oncology, Volume 19, Issue 5, Page 1386-1403, May 2025.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale   +9 more
wiley   +1 more source

Impact of the COVID-19 Pandemic on Patterns of Prescription Opioid Use: A Retrospective Cohort Study of Adults Without a Cancer Diagnosis Initiating Opioids Using Administrative Claims Data

open access: yesDrugs - Real World Outcomes, 2022
Background The coronavirus disease 2019 (COVID-19) pandemic has led to disruptions of healthcare delivery and may thus have impacted patterns of prescription opioid use, including risk factors for long-term use.
Anne-Marie Castilloux   +2 more
doaj   +1 more source

A Semi-automated Method for Domain-Specific Ontology Creation from Medical Guidelines [PDF]

open access: yesarXiv, 2021
The automated capturing and summarization of medical consultations has the potential to reduce the administrative burden in healthcare. Consultations are structured conversations that broadly follow a guideline with a systematic examination of predefined observations and symptoms to diagnose and treat well-defined medical conditions. A key component in
arxiv  

The consultation game [PDF]

open access: yesQuality and Safety in Health Care, 2004
Exploring the use of game theory to address quality Game theory and clinical practice seem an unlikely marriage and it may not be obvious how such a combination could improve the quality of clinical consultations. But this area of applied mathematics seems set to reduce some of our quintessential human foibles to a predictable set of behaviours based ...
openaire   +4 more sources

The Courteous Consult: A CONSULT Card and Training to Improve Resident Consults [PDF]

open access: yesJournal of Graduate Medical Education, 2015
Abstract Background Communication and courtesy are important elements of consultations, but there is limited published data about the quality of trainee consults. Objectives This study assessed residents' views on consult interactions,
David T. Stern   +2 more
openaire   +3 more sources

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

open access: yesMolecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld   +7 more
wiley   +1 more source

La consultation [PDF]

open access: yes, 2017
Les évolutions contemporaines de la médecine, technologiques ou managériales, numériques ou politiques, sapent les conditions d’une médecine authentiquement clinique : il importe alors d’en dégager les lignes de force qui ont traversé les âges, pour déterminer ce que nous voulons vraiment pour demain.
Plisnier, Flore, De Terwangne, Cécile
openaire   +12 more sources

Clinical Teachers’ Opinions about Bedside-based Clinical Teaching

open access: yesSultan Qaboos University Medical Journal, 2013
Objectives: In recent years, there has been a decline in estimated time spent on bedside teaching. The aim of this study was to evaluate clinical teachers’ perceptions and practice of, and approaches to, bedside teaching.
Abdullah Shehab
doaj  

Consultants in Academic Libraries: Challenging, Renewing, and Extending the Dialogue

open access: yesCanadian Journal of Academic Librarianship, 2017
There is a trend in academic libraries to hire consultants for internal crises, change management projects, strategic planning processes, outcomes assessment, evidence-based decision making, information literacy instruction, and more.
Marni R. Harrington, Ania Dymarz
doaj   +1 more source

Tocilizumab as a Therapeutic Agent for Critically Ill Patients Infected with SARS‐CoV‐2

open access: yesClinical and Translational Science, 2021
Tocilizumab is an IL‐6 receptor antagonist with the ability to suppress the cytokine storm in critically ill patients infected with severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2).
Russell M. Petrak   +25 more
doaj   +1 more source

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