Results 171 to 180 of about 36,693 (260)

A comparison of the safety of oral labetalol versus nifedipine to manage hypertension in pregnancy in Australia: a target trial emulation. [PDF]

EClinicalMedicine
Atkinson JA, Lindquist AC, Tong S, Hiscock RJ, Forsythe A, Gordon HG, Walker SP, Chua SJ, Cluver C, Myers J, Hastie RM.   +10 more
europepmc   +1 more source

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Clinical Efficacy and Biomechanical Behavior of Different Compression Systems in Venous Ulcers: Pressure, Stiffness and Healing. [PDF]

Life (Basel)
Jiménez García JF, García Ruiz MP, Jiménez FG, Gutierrez García M, Jiménez Laínez JL, Muñoz Condez M, Fernández Ramirez AB, García Fernández FP.   +7 more
europepmc   +1 more source

Engineered Optogenetic Circuits In Yeast with Self‐Sustained Outputs

Advanced Science, EarlyView.
Optogenetic quorum‐sensing (OptoQS) circuit enables Saccharomyces cerevisiae to record transient light stimulus with self‐sustained outputs. Panel a indicates the design of the OptoQS circuit based on G‐protein coupled receptor (GPCR) signaling cascade. Panel b indicates the mode of action of surrogate messenger‐mediated signal transmission at the cell
Cong Fan, Haofeng Chen, Yan Wang, Junyi Wang, Yueyang Chen, Yang Zhang, Jinting Guan, Jifeng Yuan   +7 more
wiley   +1 more source

Documented follow-up to memory concerns reported at the Medicare Annual Wellness Visit. [PDF]

Alzheimers Dement
Wec A, Wu M, Scerpella D, Zhang Z, Peereboom D, Colburn JL, Nothelle SK, Green AR, Wolff JL, Powell DS.   +9 more
europepmc   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Underweight prevalence among children under five in Sri Lanka: unpacking the role of food prices. [PDF]

BMC Nutr
Madanayaka WMGT, Fonseka KNN, Perera SD, de Silva T.   +3 more
europepmc   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Use of Claims Data to Screen for Functional Limitations Among Medicare Beneficiaries.

JAMA Health Forum
Mathews M, Martino SC, Agniel D, Hernandez HG, Beckett MK, Saliba D, Dembosky JW, Orr N, Elliott MN.   +8 more
europepmc   +1 more source

Your words, your conviction: The parallel mediation role of eWOM in the relationship between product involvement and purchase intention of smartwatches. [PDF]

BMC Psychol
Aydın G, Aydın G, Karababa B, Yılmaz O, Akkuş Y, Belli E.   +5 more
europepmc   +1 more source