Results 71 to 80 of about 4,035,157 (323)

Genetic features of the Puumala virus (Hantaviridae: Orthohantavirus) identified in the Moscow region

Вопросы вирусологии, 2023
Introduction. Puumala virus (family Hantaviridae, genus Orthohantavirus) is distributed in most regions of the European part of Russia. However, information about its genetic variants circulating on the territory of the Central Federal District is ...
Ekaterina A. Blinova, Marat T. Makenov, Evgeny S. Morozkin, Ivan S. Kholodilov, Marina V. Fedorova, Olga B. Zhurenkova, German V. Roev, Kamil F. Khafizov, Ludmila S. Karan   +8 more
doaj   +1 more source

It Depends on What the Meaning of False is: Falsity and Misleadingness in Commercial Speech Doctrine [PDF]

, 2007
While scholarship regarding the Supreme Court\u27s noncommercial speech doctrine has often focused on the level of protection for truthful, non-misleading commercial speech, scholars have paid little attention to the exclusion of false or misleading ...
Tushnet, Rebecca
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A Comparitive Assessement of Cytokine Expression in Human-Derived Cell Lines Exposed to Alpha Particles and X-Rays

The Scientific World Journal, 2012
Alpha- (α-) particle radiation exposure has been linked to the development of lung cancer and has been identified as a radiation type likely to be employed in radiological dispersal devices.
Vinita Chauhan, Matthew Howland, Ruth Wilkins   +2 more
doaj   +1 more source

Geographic information system analysis of rabies spread in island forest-steppe of East Siberia

Фундаментальная и клиническая медицина, 2019
Aim. To identify spatiotemporal features of rabies spread in island forest-steppe areas of East Siberia, a geographic region where this infection was not previously recorded among foxes.Materials and Methods.
I. D. Zarva, A. D. Botvinkin, D. V. Goryaev, P. M. Demchin, G. M. Dmitrieva, T. A. Zaykova, G. V. Lutsenko, T. G. Romanova, M. V. Rusin, O. V. Sorokina, Y. E. Suturina, E Yu. Shalginova, L. V. Shmatova   +12 more
doaj   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Genomic Profiling of a Human Leukemic Monocytic Cell-Line (THP-1) Exposed to Alpha Particle Radiation

The Scientific World Journal, 2012
This study examined alpha (α-) particle radiation effects on global changes in gene expression in human leukemic monocytic cells (THP-1) for the purposes of mining for candidate biomarkers that could be used for the development of a biological assessment
Vinita Chauhan, Matthew Howland
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Features of Decreed Groups Survey for the Presence of Pathogens of Acute Intestinal Infections During the XXII Olympic Winter Games and XI Paralympic Winter Games in Sochi

Эпидемиология и вакцинопрофилактика, 2015
The paper examines the experience of employee surveys foodservice, food contact for the presence of pathogens of acute intestinal infections during the XXII Olympic Winter Games and XI Paralympic Winter Games of 2014 in Sochi.
I. V. Bragina, B. P. Kuz'kin, E. B. Ezhlova, Yu. V. Demina, V. P. Klinduhov, T. V. Grechanaja, P. N. Nikolaevich, M. I. Balaeva, S. Ch. Tesheva, L. I. Shcherbina, V. G. Orobej, A. N. Kulichenko, D. G. Ponomarenko, D. V. Efremenko, I. V. Kuznetsova   +14 more
doaj   +1 more source