Results 21 to 30 of about 262,484 (293)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Manufacturer Strategies for Blockchain Adoption and Sales Mode Selection with a Dual-Purpose Platform

Systems
This study examines how a low-carbon manufacturer strategically adopts blockchain technology and selects sales modes with a dual-purpose e-commerce platform that focuses on both profit and consumer surplus.
Lirong Wu, Congying Duan, Qingkai Ji
doaj   +1 more source

VALUASI EKONOMI MENGGUNAKAN METODE TRAVEL COST PADA TAMAN WISATA ALAM PUNTI KAYU PALEMBANG

Jurnal Ekonomi Pembangunan, 2011
The aim of these study are to estimate the demand similarity of recreation benefit in Taman Wisata Alam Punti Kayu based on travel cost method. The similarity estimate model of recreation demand based on travel cost method that is : Y = 118,323 – 1,419 (
Muhammad Subardin
doaj   +1 more source

Government Subsidy Strategies for Biosimilars R&D Based on Dynamic Game Theory

IEEE Access, 2020
In order to develop the biomedical industry, government subsidy of biosimilars is an incentive policy which has been used by the government. Different government subsidy strategies have an impact on drug price, consumer surplus, social welfare, the ...
Yu Chen, Yipeng Lan, Zhe Huang
doaj   +1 more source

Effects of Maize Importation on the Economic Welfare of Maize Producers and Consumers in Kenya: A Partial Equilibrium Model Approach

Contemporary Agriculture, 2022
Maize imports bridge the maize supply-demand gap in Kenya. However, this does not automatically imply any positive or negative effects of such imports on the economic welfare of maize producers and consumers in the country.
Abodi Maurine Adhiambo, Obare Gideon Aiko, Kariuki Isaac Maina   +2 more
doaj   +1 more source

Competitive Mixed Bundling and Consumer Surplus [PDF]

Journal of Economics & Management Strategy, 2007
Mixed bundling in imperfectly competitive industries causes some prices to rise and others to fall. This paper studies under what conditions mixed bundling works for or against the consumer interest. We find that if buyers incur firm‐specific costs or have shop‐specific tastes then competitive mixed bundling lowers consumer surplus overall and raises ...
openaire   +3 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The impact of commercial open source software on proprietary software producers and social welfare

Journal of Industrial Engineering and Management, 2014
Purpose: A growing number of commercial open source software, based on free open source software, appears in many segments of software market. The purpose of this study is to investigate how commercial open source software affects proprietary software ...
Mingqing Xing
doaj   +1 more source