Results 31 to 40 of about 262,484 (293)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Emission-reduction investment strategies in competitive shipping supply chains under carbon cap-and-trade mechanisms

Frontiers in Marine Science
Market-based carbon cap-and-trade mechanisms play a pivotal role in reducing the carbon emissions of shipping logistics companies. Focusing on the issue of emission reduction investment in the competitive shipping logistics service supply chain (SLSSCs ...
Guangsheng Zhang, Zhaomin Zhang, Hao Yuan, Weijie Chen   +3 more
doaj   +1 more source

Competitive Price-Quality Strategy of Platforms under User Privacy Concerns

Journal of Theoretical and Applied Electronic Commerce Research, 2022
The behavior-based discrimination price model (BBPD) needs to collect a large amount of user information, which would spark user privacy concerns. However, the literature on BBPD typically overlooks consumer privacy concerns.
Xudong Lin, Xiaoli Huang, Shuilin Liu, Yulin Li, Hanyang Luo, Sumin Yu   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Food waste to blind box surprises: A study on increasing consumers' purchase intention of surplus food blind boxes

Acta Psychologica
Recently, surplus food blind boxes have emerged as a solution to reduce food waste by providing surplus ingredients at low prices. However, how to increase consumers' purchase intentions for surplus food blind boxes is still requires further study ...
Jie Sun, Xinyi Huang, Chun Yang, Wei Wei, Wei Miao, Chao Gu   +5 more
doaj   +1 more source

Estimating Producer's Surplus with the Censored Regression Model: An Application to Producers Affected by Columbia River Basin Salmon Recovery

Journal of Agricultural and Resource Economics, 2000
Application of the tobit model to estimate economic welfare is transferred from the consumer side to the producer side. Supply functions are estimated for multioutput irrigators in the Pacific Northwest.
Michael R. Moore, Noel R. Gollehon, Daniel Hellerstein   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Effects of the buy-online-and-assemble-in-store approach: Implications for firms, consumers, and environment

Sustainable Operations and Computers
The buy-online-and-assemble-in-store (BOAS) approach has been implemented by different contemporary firms (i.e. IKEA and TUHU); however, the implications of BOAS for firms, consumers, and environment remain unclear. To fill this gap, this study considers
Guanxiang Zhang, Xiangzhen Meng, Lipan Feng, Qi Kou   +3 more
doaj   +1 more source

Effects of Serbian accession to the European Union [PDF]

Panoeconomicus, 2012
In this article, the global simulation model (GSIM) of Joseph F. Francois and Keith H. Hall (2009) for analyzing global, regional, and unilateral trade policy changes was applied to Serbia.
Holzner Mario, Ivanić Valentina
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source