Results 41 to 50 of about 285,974 (264)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

EPIDEMIOLOGICAL RISK OF INTRODUCTION OF DANGEROUS AND EXOTIC INFECTIOUS DISEASES ON THE TERRITORY OF THE XXII OLYMPIC WINTER GAMES AND XI PARALYMPIC WINTER GAMES 2014 IN SOCHI

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
To assess the epidemiological risk of introduction of serious infectious diseases in the pre-Olympic period defined list of dangerous and exotic infections and held assessment ofpotential danger threatening.
B. P Kuzkin, E. B Ezhlova, A. N Kulichenko, O. V Maletskaya, Yu. V Demina, T. V Taran, N. D Pakskina, T. V Kharchenko, G. M Grizhebovsky, V. N Savelev, V. G Oroby, V. P Klindukhov, T. V Grechanaya, S. Ch Tesheva, G. D Bryukhanova   +14 more
doaj  

Morbidity Rates of Q Fever in the Russian Federation and European Countries: Realities and Problems

Проблемы особо опасных инфекций, 2015
Q fever poses a problem, both in the Russian Federation and abroad. Thereat, a new base normative document, sanitary-epidemiological regulations on coxiellosis prevention, has been developed and approved in the Russian Federation. For the first time ever
E. A. Yakovlev, S. V. Borisevich, A. Yu. Popova, E. B. Ezhlova, Yu. V. Demina   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Innovations and risk in entrepreneurship

Путеводитель предпринимателя, 2020
In article theoretical aspects of business activity in the innovative environment in which the risk and uncertainty are inherent are considered.
Y. V. Sakharnov
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

PRINCIPLE DIRECTIONS FOR THE CREATION AND ORGANIZATION OF THE SYSTEM OF SANITARY-EPIDEMIOLOGICAL SAFETY DURING THE PREPARATIONS FOR THE XXII OLYMPIC WINTER GAMES AND XI PARALYMPIC WINTER GAMES 2014 IN SOCHI

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
The paper generalizes the experience of formation of protection system against biological threats and ensuring sanitary and epidemiological welfare during preparation for the XXII Olympic Winter Games and XI Paralympic Winter Games of 2014 in Sochi.
G. G Onischenko, I. V Bragina, E. B Ezhbva, Yu. V Demina, A. A Gorsky, A. S Guskov, O. I Aksenova, G. E Ivanov, V. P Klindukhov, P. N Nikolaevich, T. V Grechanaya, A. N Kulichenko, O. V Maletskaya, E. A Manin, V. V Parkhomenko, O. A Kulichenko   +15 more
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Epidemiological Features of New Coronavirus Infection (COVID-19). Communication 1: Modes of Implementation of Preventive and Anti-Epidemic Measures

Проблемы особо опасных инфекций, 2020
The review analyses the information on the epidemiological situation on COVID-19 around the world. Presented is the assessment of the major epidemiological parameters (basic reproductive rate, lethality, incubation period, and serial interval ...
V. V. Kutyrev, A. Yu. Popova, V. Yu. Smolensky, E. B. Ezhlova, Yu. V. Demina, V. A. Safronov, I. G. Karnaukhov, A V. Ivanova, S. A. Shcherbakova   +8 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source