Results 111 to 120 of about 354,127 (316)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Double dividend : promoting good nutrition and sustainable consumption through healthy school meals

open access: yes, 2012
This report, produced by the Sustainable Consumption Roundtable tackles the issues surrounding promoting good nutrition and sustainable consumption through healthy school meals.Publisher ...
Soil Association   +6 more
core  

The marketplace management of illegal elixirs : illicit consumption of rhino horn

open access: yes, 2016
This article examines the consumption of illegally traded rhino horn. We conducted a survey on 608 males in Vietnam, a country that is identified as among the world's largest recipients of illicit rhino horn.
Truong, V. Dao,   +2 more
core   +1 more source

Tüketim Hedonizminden Gözetime Açık Bilet: HOPİ Akıllı Kart Uygulaması Örneği

open access: yesYeni Medya, 2018
Modern birey kapitalist tüketim kültürünün kendisine yaşattığı tüketim hazzını yaşamak ve kendisini “o” ürünü tüketerek bir statünün içine dahil etmek hayalindedir.
Gözde Şahin
doaj  

Between Two Worlds: an Ethnographic Study of Gay Consumer Culture in Rio de Janeiro [PDF]

open access: yesBAR: Brazilian Administration Review, 2012
It is not easy to study socially marginalized groups such as gays, ethnic minorities, and others. This is, however,an extremely relevant topic in the consumer behavior area since the status of members of a modern consumersociety is largely denied to ...
Severino Joaquim Nunes Pereira   +1 more
doaj  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Consumption culture and furniture: An analysis of two Turkish housing spaces [PDF]

open access: yes, 2019
Today, with the influence of globalization, the diversity of consumer groups with different consumption habits has increased and producers have had to offer products to a much wider range of consumers.
Aras, Aylin, Ozdemir, Ilkay Masat
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

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