Results 91 to 100 of about 3,412,277 (344)

Residual stresses caused by static and dynamic contact interaction of composite plate and steel spherical indenter

open access: yesFracture and Structural Integrity
A new approach has been developed and implemented to determine the main components of residual stresses that arise as a result of the contact interaction of a spherical indenter and a flat surface of composite plate made.
Sviatoslav Eleonsky, Vladimir Pisarev
doaj   +1 more source

Frictional dissipation of polymeric solids vs interfacial glass transition

open access: yes, 2006
We present single contact friction experiments between a glassy polymer and smooth silica substrates grafted with alkylsilane layers of different coverage densities and morphologies. This allows us to adjust the polymer/substrate interaction strength. We
B. N. J. Persson   +3 more
core   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

DETERMINATION OF CONTACT STRESSES IN THE RAILS P50, WHICH ARE OPERATED IN THE METRO

open access: yesNauka ta progres transportu, 2015
Purpose. In the research one should do: 1) to determine a 3-d stress-strain state of the rail head in contact with the rolling wheels; 2) to analyze different forms of contact interaction; 3) to obtain the data necessary to calculate the durability of ...
O. V. Agarkov, R. M. Yosufovuch
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

FILTRATION AND MICRO-RHEOLOGICAL ANOMALIES OF POLYMER DRILLING SOLUTIONS

open access: yesИзвестия высших учебных заведений: Нефть и газ, 2019
The article pays attention to the fact that biopolymer drilling solutions without a solid phase acquire viscoelastic properties in a porous medium that are not fixed by means of standard drilling rheometry.
O. F. Kondrashev
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Modern Condition, Analysis of Work and Prospects of Development of Intermediate Rail Fastenings

open access: yesМеханика машин, механизмов и материалов, 2019
The object of the study is intermediate rail fastenings used to attach rails to sleepers. The monitoring of technical characteristics and economic indicators of structures of domestic and foreign production with the analysis of their work is given.
Dmitry I. Boсhkaryov   +1 more
doaj  

Numerical modeling of the processes of deformation and buckling of multilayer shells of revolution under combined quasi-static and dynamic axisymmetric loading with torsion [PDF]

open access: yesИзвестия Саратовского университета. Новая серия: Математика. Механика. Информатика
A two-dimensional formulation and method for numerical solution of problems of deformation and loss of stability of multilayer elastoplastic shells of rotation under quasi-static and dynamic axisymmetric loading with torsion have been developed.
Bazhenov, Valentin G.   +3 more
doaj   +1 more source

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