Results 71 to 80 of about 2,661,721 (287)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Method for fabricating solar cells having integrated collector grids [PDF]
, 1979 A heterojunction or Schottky barrier photovoltaic device comprising a conductive base metal layer compatible with and coating predominately the exposed surface of the p-type substrate of the device such that a back surface field region is formed at the ...
Evans, J. C., Jr.
core +1 more source
Optimal curing policy for epidemic spreading over a community network with heterogeneous population
, 2017 The design of an efficient curing policy, able to stem an epidemic process at an affordable cost, has to account for the structure of the population contact network supporting the contagious process.
Bonaccorsi, Stefano +3 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Refined Contact Map Prediction of Peptides Based on GCN and ResNet
Frontiers in Genetics, 2022 Predicting peptide inter-residue contact maps plays an important role in computational biology, which determines the topology of the peptide structure. However, due to the limited number of known homologous structures, there is still much room for inter ...
Jiawei Gu +9 more
doaj +1 more source
Hybrid performance modelling of opportunistic networks [PDF]
, 2012 We demonstrate the modelling of opportunistic networks using the process algebra stochastic HYPE. Network traffic is modelled as continuous flows, contact between nodes in the network is modelled stochastically, and instantaneous decisions are modelled ...
Bortolussi, Luca +2 more
core +3 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
VSTP: vessel spatio-temporal contact pattern detection based on MapReduce
EURASIP Journal on Wireless Communications and Networking, 2017 Due to lack of the coverage of 3G/4G network, satellite communication which costs excessively is the main approach used in ocean to provide network service. Ocean mobile delay tolerant network (OMDTN) can provide low-cost data transmission service in the
Chao Liu +5 more
doaj +1 more source
Contact Heterogeneity and Phylodynamics: How Contact Networks Shape Parasite Evolutionary Trees [PDF]
Interdisciplinary Perspectives on Infectious Diseases, 2011 The inference of population dynamics from molecular sequence data is becoming an important new method for the surveillance of infectious diseases. Here, we examine how heterogeneity in contact shapes the genealogies of parasitic agents. Using extensive simulations, we find that contact heterogeneity can have a strong effect on how the structure of ...
Eamon B. O'Dea, Claus O. Wilke
openaire +3 more sources