Results 41 to 50 of about 746,127 (308)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Investigation of the Influence of Contact Patterns of Worm-Gear Sets on Friction Heat Generation during Meshing

Applied Sciences
Friction losses and scuffing failures are interesting research topics for worm gears. One of the factors leading to scuffing is the heat generated in the contact of gear teeth.
Aleksandar Miltenović, Milan Banić, Nikola Vitković, Miloš Simonović, Marko Perić, Damjan Rangelov   +5 more
doaj   +1 more source

Reflections from COVID-19 Pandemic: Contact Diary for Assessing Social Contact Patterns in Nepal

Journal of Nepal Health Research Council, 2020
Management of COVID-19 in Nepal will certainly benefit from the experiences of other countries. However, they are less likely to be suitable for Nepal both in terms of context and resource availability.
Niraj Shrestha, Achyut Raj Pandey, Mirak Raj Angdembe   +2 more
doaj   +1 more source

Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse [PDF]

, 2002
Receptor-ligand couples in the cell-cell contact interface between a T cell and an antigen-presenting cell form distinct geometric patterns and undergo spatial rearrangement within the contact interface.
Nigel John Burroughs, Burroughs, Nigel John, Wülfing, Christoph, Christoph Wülfing   +3 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Improved Contact Predictions Using the Recognition of Protein Like Contact Patterns

PLoS Computational Biology, 2014
Given sufficient large protein families, and using a global statistical inference approach, it is possible to obtain sufficient accuracy in protein residue contact predictions to predict the structure of many proteins. However, these approaches do not consider the fact that the contacts in a protein are neither randomly, nor independently distributed ...
Skwark, Marcin J., Raimondi, Daniele, Michel, Mirco, Elofsson, Arne   +4 more
openaire   +9 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Word-Formation Pattern Borrowing in Latvian

Baltic Journal of English Language, Literature and Culture, 2018
English as the main contact language during the last three decades has affected Latvian word-formation patterns, patterns of use and patterns of convention. This is pattern borrowing, in addition to phonological borrowing which is also rife. Part of this
Andrejs Veisbergs
doaj   +1 more source

Tooth Contact Patterns at the Mandibular Retruded Contact Position

Nihon Hotetsu Shika Gakkai Zasshi, 2003
目的: 後方歯牙接触の顎機能に対する影響を検討する目的で, 健常有歯顎の被験者を対象として後方歯牙接触部位の記録を行い, これらの部位が歯列内においてどのように分布しているのかを分析した.方法: 被験者は健常有歯顎者283名とした. 術者は下顎の最後方位への誘導術式に十分習熟した歯科医師1名とし, 下顎頭が最後方位に誘導された際の歯牙接触部位に関して, 咬合紙を用いて記録した. 分析は, 接触歯の側性, 接触歯種, 接触歯数の3項目について, 接触歯群に基づく被験者の分類を加味して行った.結果: 1. 接触様式が両側性の被験者と片側性の被験者との比率は約6: 4であった. 2. 接触頻度の高かった接触歯種は, 第一小臼歯, 第二大臼歯の順であった. 3. 接触歯数は約8割の被験者で2歯以内であった.
Yamashita, Shuichiro, Kirihara, Takanao, Igarashi, Yoshimasa, Ai, Minoru   +3 more
openaire   +2 more sources

Allergic contact dermatitis from dicyclohexylmethane-4,4 '-diisocyanate [PDF]

, 2003
From August 1999 to April 2001, there was an outbreak of severe eczema at a factory manufacturing medical equipment. A glue, mainly based on the isocyanate dicyclohexylmethane-4,4'-diisocyanate (DMDI), was suspected as being the cause of the problem.
Hamnerius, N, Engfeldt, Malin,, Björkner, Bert,, Lund University., Zimerson, Erik,   +4 more
core   +1 more source