Results 91 to 100 of about 4,605,487 (285)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Relation between contact area and adhesion behaviour between viscoelastic food systems and processing surfaces – influence of rheology and contact time

Applied Food Research
The adhesion between solid processing surfaces and viscoelastic food systems strongly depends on the surface structure and increases with contact time.
Rita Laukemper, Mario Jekle, Thomas Becker   +2 more
doaj   +1 more source

Space time manifolds and contact structures

International Journal of Mathematics and Mathematical Sciences, 1990
A new class of contact manifolds (carring a global non-vanishing timelike vector field) is introduced to establish a relation between spacetime manifolds and contact structures.
K. L. Duggal
doaj   +1 more source

Lie contact structures and conformal structures [PDF]

Kodai Mathematical Journal, 1991
The author continues investigations of Lie contact structures [ibid., 13- 41 (1991; see the review above)] and computes the curvature K of the Tanaka connection associated to the Lie contact structure on a unit tangent bundle \(T_ 1M\) of a Riemannian manifold M. This curvature is strictly related to Weyl's conformal curvature of M.
openaire   +3 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Contact stress analysis and optimization of single crystal turbine blade tenon/disk mortise structure considering thermal-solid coupling

MATEC Web of Conferences, 2017
Contact stress analysis and optimization design of single crystal turbine blade tenon/disk mortise structure considering thermal-solid coupling is proposed in this paper.
Li Lei, Tang Zhonghao, Deng Dingyuan, Zhang Mengchuang, Yu Jiawei   +4 more
doaj   +1 more source

CRNPRED: highly accurate prediction of one-dimensional protein structures by large-scale critical random networks

BMC Bioinformatics, 2006
Background One-dimensional protein structures such as secondary structures or contact numbers are useful for three-dimensional structure prediction and helpful for intuitive understanding of the sequence-structure relationship.
Kinjo Akira R, Nishikawa Ken
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Analysis of electric repulsion on contacts of different molded case circuit breakers

AIP Advances
The electric repulsion between the movable contact and static contact of molded case circuit breakers (MCCBs) will directly affect the breaking speed of the movable contact, which in turn affects its breaking capacity.
Jie Zhang, Bowang Wang, Mengjiao Ye, Xiaogang Pi, Yingbo Huang   +4 more
doaj   +1 more source