Results 61 to 70 of about 2,866 (208)

Contact tracing for HIV infection [PDF]

BMJ, 1988
The logistics of contact tracing for human immunodeficiency virus (HIV) are daunting given that 1-1.5 million people are infected in the US. Early infection is often asymptomatic; the incubation period is uncertain; there is no effective treatment for asymptomatic disease; and diagnosis confers few benefits and several disadvantages on the individual ...
M W, Adler, A M, Johnson
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Privacy and contact tracing efficacy

Journal of the Royal Society Interface, 2022
Abstract As the COVID-19 pandemic emerged, public health authorities and software designers considered the possibility that smartphones could be used for contact tracing to control disease spread. Smartphone-based contact tracing was attractive in part because it promised to allow the tracing of contacts that might not be reported ...
Sebastian Benthall, Erez Hatna, Joshua M. Epstein, Katherine J. Strandburg   +3 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Evaluation of contact tracing performance during an Ebola virus disease outbreak in a complex security environment: the case of North Kivu province, Democratic Republic of the Congo, 2018–2020

Conflict and Health
Background Contact tracing remains a pillar public health strategy for containing Ebola virus disease (EVD). During the 2018–2020 EVD outbreak in the Democratic Republic of the Congo (DRC), contact tracing was implemented on an unprecedented scale. Here,
Willy Ngalamulume, Harry César Kayembe, Guy Mutombo, Mathias Mossoko, Annie Mutombo, Didier Bompangue   +5 more
doaj   +1 more source

A Person-to-Person and Person-to-Place COVID-19 Contact Tracing System Based on OGC IndoorGML

ISPRS International Journal of Geo-Information, 2020
With the wide availability of low-cost proximity sensors, a large body of research focuses on digital person-to-person contact tracing applications that use proximity sensors.
Soroush Ojagh, Sara Saeedi, Steve H. L. Liang   +2 more
doaj   +1 more source