Results 101 to 110 of about 4,939,313 (338)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
A Resolution Independent Solution for Confined Axisymmetric Vortex Breakdown Flow
Journal of Fluid Science and Technology, 2007 Numerical simulation is performed for the vortex breakdown flows induced in a cylindrical container with rotating top disk. Solutions are obtained for the parameter ranges where steady axisymmetric flows are stable with respect to asymmetric disturbances.
Reima IWATSU, Hide S. KOYAMA
doaj +1 more source
, 2012 Recent research on maritime ports hinterlands points out the relevance of mass ground transport modes such as barge transport for enormous flows of containers to and from harbours, especially when a maritime port is located at the mouth of a river ...
Fischman, Marianne, Lendjel, Emeric
core +1 more source
Liquid encapsulated float zone process and apparatus [PDF]
, 1988 The process and apparatus for growing crystals using float zone techniques are described. A rod of crystalline materials is disposed in a cylindrical container, leaving a space between the rod and container walls. This space is filled with an encapsulant,
Facemire, Barbara R. +4 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Analysis of Turbulent Free Convection in a Rectangular Rayleigh-Benard Cell [PDF]
, 2007 The present study compares results of direct numerical simulations of thermal convection within a rectangular geometry with Rayleigh-Benard convection in thin fluid layers and cylindrical geometries.
Kaczorowski, Matthias, Wagner, Claus
core
, 2018 In order to enhance the understanding of membrane fouling mechanism, the hydrodynamics of granular flow in a stirred enzymatic membrane reactor was numerically investigated in the present study.
Hu, Xu-Qu +4 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source