Results 171 to 180 of about 9,986 (299)

A Low-Code Containerized Edge Architecture for IIoT Telemetry Orchestration: Mitigating Cloud API Rate Limits Through Dual-Path Routing. [PDF]

Sensors (Basel)
Rosa-Bilbao J.
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Ship wake field analysis using a coupled BEMt-RANS approach

The prediction of a ship’s wake field and self-propulsion capabilities has traditionally been centered on experiments; however with the advancement in modern computing power, this can be achieved through the use of computational methods.
Badoe, C., Turnock, S.R., Phillips, A.B.
core  

Technological architecture for a multi-region solution within the regulation of Brazil's Unified Health System. [PDF]

Front Digit Health
Cardoso PH, Barreto TO, Valentim JLRDS, Coutinho KD, Dos Santos JPQ, de Morais AHF, Veras NVR, Portela AEA, Melo JS, Barros CDC, Pinheiro AS, Dantas MB, Paiva JCL, Filho JAP, de Almeida RS, Júnior WDS, da Silva AM, de Melo EAS, da Silva DLI, Crisostomo JVM, Dos Santos SRFC, Veloso CMFM, Machado GM, Valentim RAM.   +23 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Systemic impacts of disruptions at maritime chokepoints. [PDF]

Nat Commun
Verschuur J, Lumma J, Hall JW.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Computational Fluid Dynamic Analysis of Fluid Motion and Volumetric Gas-Liquid Mass Transfer in Agitated Platelet Concentrate Storage. [PDF]

Biotechnol J
Pym D, Davies AJ, Williams JO, Saunders C, George CE, Mason-Jones A, James PE.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Analytical fleet-sizing method for the Open Platform for Innovation in Logistics (OPIL). [PDF]

Sci Rep
Körösi L, Duchoň F.
europepmc   +1 more source