Results 191 to 200 of about 414,114 (349)

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Forecasting China's shipping indices based on modal decomposition and optimized deep learning integrated model. [PDF]

PLoS One
Zou Y, Liu Y, Xiao G.
europepmc   +1 more source

Population pharmacokinetics of levofloxacin in breastmilk in patients with rifampicin‐resistant tuberculosis

British Journal of Clinical Pharmacology, EarlyView.
Levofloxacin is a widely used antibiotic included in rifampicin‐resistant tuberculosis (RR‐TB) treatment. Data describing levofloxacin concentrations in breastmilk and infant exposure are limited. We analysed data from two South African studies of breastfeeding women receiving levofloxacin (750–1000 mg daily) for RR‐TB.
Sharon Sawe, Lufina Tsirizani, Buyisile Mkhize, Lubbe Wiesner, Gary Maartens, Francesca Conradie, Richard Court, Marian Loveday, Catriona Waitt, Paolo Denti   +9 more
wiley   +1 more source

Arctic Sea Route access reshapes global shipping carbon emissions. [PDF]

Nat Commun
Zhao P, Li Y, Zhang C, Kang T, He Z, Huang G, Zhang S, Zhang X, Xu Y, Kong W.   +9 more
europepmc   +1 more source

Young people's occupational aspirations beyond the aspiration discourse: A sociocultural perspective

British Educational Research Journal, EarlyView.
Abstract Young people's aspirations have been the focus of many educational, sociological and psychological studies. This paper argues, firstly, that the concept of aspirations holds greater generative potential than suggested by the policy‐oriented ‘aspiration discourse’.
Jelena Popov
wiley   +1 more source

How do ferry operators communicate their engagement with sustainability issues? Comparison of the Baltic and the Adriatic ferry operators. [PDF]

PLoS One
Wagner N, Hącia E, Łapko A, Strulak-Wójcikiewicz R, Mrčelić GJ, Marušić E.   +5 more
europepmc   +1 more source

Systemic impacts of disruptions at maritime chokepoints. [PDF]

Nat Commun
Verschuur J, Lumma J, Hall JW.
europepmc   +1 more source

A review of the historic and present ecological role of aquatic and shoreline wood, from forest to deep sea

Biological Reviews, EarlyView.
ABSTRACT The ecology of forests, their losses, and terrestrial wood decomposition dynamics have been intensively studied and reviewed. In the aquatic realm, reviews have concentrated on large wood (LW) in rivers and the transition from freshwater to marine environments in the Pacific Northwest of North America. However, a comprehensive global synthesis
Jon Dickson, Ellen Wohl, Laura L. Govers, Oscar Franken, Tjeerd J. Bouma, Han Olff, Britas Klemens Eriksson, Maryann S. Watson, Luísa M.S. Borges, Tjisse van der Heide   +9 more
wiley   +1 more source

Assessing the impact of ship emissions on the atmospheric chemical composition in the Eastern Mediterranean and the Piraeus port (Greece). [PDF]

Sci Rep
Poupkou A, Liora N, Kontos S, Grivas G, Fameli KM, Tsiaousidis D, Solomos S, Kapsomenakis I, Assimakopoulos V, Progiou A, Kalabokas P, Mihalopoulos N, Kotrikla AM, Melas D, Zerefos C.   +14 more
europepmc   +1 more source

Shaping research in marine functional connectivity for integrated and effective marine science and management

Biological Reviews, EarlyView.
ABSTRACT Effective knowledge of ecological connectivity at sea and at the land–sea interface is key to supporting global policy goals to conserve and restore ocean biodiversity and function. However, a persistent lack of commonality in terminology and understanding around the concept of connectivity in marine ecological studies hampers its integration ...
Audrey M. Darnaude, Susanne E. Tanner, Andreu Blanco, Anna M. Sturrock, Yael Teff Seker, Angel Pérez‐Ruzafa, Jonne Kotta, Tamar Guy‐Haim, Francisco R. Barboza, Manuel Hidalgo, Katell Guizien, Jerneja Penca, Lucía López‐López, Maria Beger, Federica Costantini, Sophie Arnaud‐Haond, Cynthia Riginos, Kris Hostens, Gil Rilov, Stelios Katsanevakis, Ewan Hunter   +20 more
wiley   +1 more source