Results 71 to 80 of about 7,283 (299)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Accessibility of Containers Stacked in Container Terminals

open access: yesJournal of the Society of Naval Architects of Japan, 1992
Containers are stowed in stacked condition in most of the container terminals. In this case, access to a designated container, especially to import container, is one of serious problems for terminal operation. Because handling to deliver import containers to consignees is usually carried out, in order of the arrival of their trucks to the terminal ...
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

NEW TECHNOLOGIES ON CONTAINER TERMINALS [PDF]

open access: yes, 2020
Namen diplomske naloge je predstaviti nove tehnologije na kontejnerskih terminalih. V prvem delu diplomske naloge je predstavljeno na splošno o kontejnerskem transportu.
Bišćan Pečarič, Anja
core   +1 more source

Examining Container Terminal Efficiency with Diverse Data Sources: Vessel, Truck, and Container Turnaround Times in Japanese Terminals

open access: yesLogistics
Background: Improving container terminal efficiency requires a comprehensive understanding of the interactions between vessel, truck, and container operations, yet existing studies often analyzed these components separately.
Daigo Shiraishi   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

A Simulation based model for the berth allocation and quay crane assignment problem [PDF]

open access: yes
With the global development of container transport, container terminals have become important nodes in transport networks which serve as hubs for the transshipment of containerized goods from ship to ship or from ship to other transport modes.
Abdel Hafez, M.A.   +3 more
core  

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