Results 101 to 110 of about 6,321,849 (288)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Mobility-aware Software-Defined Service-Centric Networking
, 2022 Future Internet applications, such as the vehicular use cases, impose requirements that challenge current networking paradigms. Hence, other networking paradigms have been proposed, such as Software-Defined Networking (SDN) and Information-Centric ...
Braun, Torsten +3 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Enhanced Forwarding Strategies in Information Centric Networking [PDF]
, 2015 Content Centric Networking (CCN), a Clean Slate architecture to Information Centric Networking (ICN) , uses new approaches to routing named content, achieving scalability, security and performance.
Udugama, Asanga
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A Cache Management Scheme for Efficient Content Eviction and Replication in Cache Networks
IEEE Access, 2017 To cope with the ongoing changing demands of the internet, `in-network caching' has been presented as an application solution for two decades. With the advent of information-centric network (ICN) architecture, `in-network caching' becomes a network level
Muhammad Bilal, Shin-Gak Kang
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
High Performance Content Centric Networking on Virtual Infrastructure [PDF]
, 2013 Content Centric Networking (CCN) is a novel networking architecture in which communication is resolved based on names, or descriptions of the data transferred instead of addresses of the end-hosts.
Tang,
core +2 more sources