Results 141 to 150 of about 35,615,848 (369)

Determinants in the on-line distribution of digital content: an exploratory analysis [PDF]

open access: yes, 2012
This article shows the phases – and discusses the results – of an empirical analysis addressing the legal business models that are adopted online to distribute digital ...
Borghi, Maurizio   +3 more
core  

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

The "Internet marketing" category in the institutional discourse: content analysis of web pages [PDF]

open access: yes, 2017
Статья посвящена количественному анализу элементов контекстов употребления концепта «Интернет-маркетинг» в сети Интернет. Автором проведена содержательная интерпретация фрагментов контекстов употребления концепта, определена их частотность, с целью ...
Пухир, Е. А.   +1 more
core  

Expectations of Faculty of Nursing Schools in Tehran on Administrative Management of Schools: A qualitative study [PDF]

open access: yesحیات, 2012
Background & Aim: Motivated faculty promotes nursing students' educational level which leads to community health promotion. Attempts should be made to recognize and analyze motivating factors including expectations.
Abolfazl Rahimi   +3 more
doaj  

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

open access: yesFEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri   +5 more
wiley   +1 more source

Protein kinase FAM20C—when subcellular localization matters

open access: yesFEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

open access: yesFEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker   +9 more
wiley   +1 more source

Commentaires des jeunes sur une économie en croissance : échos de la Nouvelle-Zélande de 1884 à 1914

open access: yesEnfances, Familles, Générations, 2017
Research Framework : Over the thirty years before World War I, expansion of the world economy occasioned new opportunities and new constraints for children and adolescents as well as adults; but experiences and responses of minors are understated in ...
Sherry Olson, Peter Holland
doaj  

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