Results 81 to 90 of about 35,615,848 (369)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Identifikasi Kuliner Lokal Indonesia dalam Pembelajaran Bahasa Inggris

open access: yesJurnal Pariwisata Terapan, 2017
This study is aimed at identifying the representation of local foods and beverages in English textbooks used in Indonesia. Based on the current curriculum, character building should be promoted as one of the learning goals. This effort is to maintain and
Agnes Siwi Purwaning Tyas
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Selecting ELL Textbooks: A Content Analysis of L2 Learning Strategies [PDF]

open access: yes, 2010
Although middle school teachers use a variety of ELL textbooks, many lack effective criteria to critically select materials that represent a wide range of L2 learning strategies. This study analyzed the illustrated and written content of 33 ELL textbooks
LaBelle, Jeffrey
core   +1 more source

Meeting the loose ends with ethnographic content analysis

open access: yesRevista Debates, 2015
Having the basis for a better, deeper and sustained discussion over a selected content and problem is one of the challenges one may face when a traditional research technique, such as content analysis, is applied in a less common approach as is ...
Paula do Espírito Santo, Isabel Soares
doaj  

Self-Reported Patterns of Use of Alcohol and Drugs After Suicide Bereavement and Other Sudden Losses: A Mixed Methods Study of 1,854 Young Bereaved Adults in the UK

open access: yesFrontiers in Psychology, 2020
BackgroundBereavement, particularly by suicide, is associated with an excess risk of mortality and of physical and psychological morbidity. Use of alcohol as a coping mechanism is suggested as a contributing factor.
Alexandra Pitman   +5 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

Analysis of Secretary Job Advertisement Content for Secretarial Skills Needs

open access: yesJurnal Economia, 2020
: This paper aimed to identify and formulate the labor market demand on works skills for secretary indicated in job advertisements. The study conducted from February to July 2019. The particular research used content analysis with a qualitative approach.
Purwanto Purwanto   +2 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

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