MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Leftover bandwidth-aware peer selection algorithm for inter-datacenter content distribution
Tongxin xuebao, 2013 Due to the fact that leftover bandwidth appears during non-overlapping time intervals, an approach of using such bandwidth to distribute delay tolerant data was proposed, and then a distributs and scalable leftover band-width-aware peer selection ...
Yong-feng HUANG +3 more
doaj
Linking mixing processes and climate variability to the heat content distribution of the Eastern Mediterranean abyss. [PDF]
Sci Rep, 2018 Artale V +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Moisture Content Distribution in Cross-Section of Cylindrical Wood Components. [PDF]
Polymers (Basel)Tian P, Zhang H, Han J, Zhao Y, Han X.
europepmc +1 more source
An Efficient Framework for Large Scale Multimedia Content Distribution in P2P Network: I2NC. [PDF]
ScientificWorldJournal, 2015 Anandaraj M +3 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Influence of Solid Content Distribution on the Low-Field Nuclear Magnetic Resonance Characterization of Ferric-Containing Alkali-Activated Materials. [PDF]
Materials (Basel)Tang Z, Song Y, Li W, Zhang L.
europepmc +1 more source
Genome-wide analysis of a recently active retrotransposon, Au SINE, in wheat: content, distribution within subgenomes and chromosomes, and gene associations. [PDF]
Plant Cell Rep, 2018 Keidar D, Doron C, Kashkush K.
europepmc +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source