Results 101 to 110 of about 1,107,060 (390)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Micro- Foundation for Non-Deterministic Contests of the Logit Form [PDF]

In models of non-deterministic contest, players exert irreversible effort in order to increase their probability of winning a prize. The most prominent functional form of the win probability in the literature is the so-called “logit” contest success ...
Matthias Dahm, Nicolas Porteiro
core  

The DNA60IFX contest

Genome Biology, 2013
We present the full story of Genome Biology's recent DNA60IFX contest, as told by the curators and winner of what turned out to be a memorable and hotly contested bioinformatics challenge.
Schatz, M. C., Taylor, J., Schelhorn, S. E.   +2 more
openaire   +4 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Hoy será mi día...

Káñina, 2008
Posición estática e inmutable. Mirada fija en las jugadas del partido. Nada lo distrae. Manos en la cintura, solo las mueve de ahí para prender un cigarrillo, luego otro, y otro más...
Esteban Guevara Solís
doaj  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Fantasía 83

Káñina, 2008
Es muy sencilla, en realidad. Yo estoy sentada en mi cama pero cobijada. Tengo el pelo recogido, para que no me estorbe en la cara.
Marisol Fonseca Malavasi
doaj  

A General Model of Bertrand–Edgeworth Duopoly

Games
This paper studies a class of two-player all-pay contests with externalities that encompass a general version of duopoly price competition. This all-pay contest formulation puts little restriction on production technologies, demand, and demand rationing.
Blake A. Allison, Jason J. Lepore
doaj   +1 more source

THE Economics of Match-Fixing [PDF]

The phenomenon of match-fixing does constitute a constant element of sport contests. This paper presents a simple formal model in order to explain it. The intuition behind is that an asymmetry in the evaluation of the stake is the key factor leading to ...
Caruso, Raul
core   +1 more source

Scissors [PDF]

, 2013
2014 essay contest winner Sharon Gollery\u27s ...
Gollery, Sharon
core   +1 more source