Results 151 to 160 of about 1,107,060 (390)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Optimal punishment in contests with endogenous entry
, 2013 Jonathan P. Thomas, Zhewei Wang
openalex +2 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Annotating in the Margins: Generation 1 Learners' Resistance Through Language/Identity in Sites of Contestation [PDF]
, 2019 Emily K. Suh
openalex +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Unifying Contests: from Noisy Ranking to Ratio-Form Contest Success Functions [PDF]
This paper proposes a multi-winner noisy-ranking contest model. Contestants are ranked in a descending order by their perceived outputs, and rewarded by their ranks.
Fu, Qiang, Lu, Jingfeng
core +4 more sources
Contest partitioning in binary contests
Autonomous Agents and Multi-Agent SystemsAbstractIn this work we explore the opportunities presented by partitioning contestants in contest into disjoint groups, each competing in an independent contest, with its own prize. This, as opposed to most literature on contest design, which focuses on the setting of a single “grand” (possibly multi-stage) contest, wherein all potential contestants ...
Priel Levy, Yonatan Aumann, David Sarne
openaire +1 more source