Results 71 to 80 of about 767,182 (284)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Regular realizability problems and context-free languages

, 2015
We investigate regular realizability (RR) problems, which are the problems of verifying whether intersection of a regular language -- the input of the problem -- and fixed language called filter is non-empty. In this paper we focus on the case of context-
A Yakaryılmaz, J Berstel, J Berstel, L Boasson, L Boasson, L Pierre, L Pierre, MN Vyalyi, MN Vyalyi, R Greenlaw, SA Greibach, T Anderson   +11 more
core   +1 more source

Bracketed context-free languages

Journal of Computer and System Sciences, 1967
AbstractA bracketed grammar is a context-free grammar in which indexed brackets are inserted around the right-hand sides of the rules. The language generated by a bracketed grammar is a bracketed language. An algebraic condition is given for one bracketed language to be a subset of another. The intersection and the difference of two bracketed languages
Ginsburg, Seymour, Harrison, Michael A.
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CodeMaster - Automatic Assessment and Grading of App Inventor and Snap! Programs

Informatics in Education, 2018
The development of computational thinking is a major topic in K-12 education. Many of these experiences focus on teaching programming using block-based languages.
Christiane Gresse von WANGENHEIM, Jean C. R. HAUCK, Matheus Faustino DEMETRIO, Rafael PELLE, Nathalia da CRUZ ALVES, Heliziane BARBOSA, Luiz Felipe AZEVEDO   +6 more
doaj   +1 more source

Presenting Distributive Laws [PDF]

Logical Methods in Computer Science, 2015
Distributive laws of a monad T over a functor F are categorical tools for specifying algebra-coalgebra interaction. They proved to be important for solving systems of corecursive equations, for the specification of well-behaved structural operational ...
Marcello M. Bonsangue, Helle Hvid Hansen, Alexander Kurz, Jurriaan Rot   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

On Second-Order Monadic Monoidal and Groupoidal Quantifiers [PDF]

Logical Methods in Computer Science, 2010
We study logics defined in terms of second-order monadic monoidal and groupoidal quantifiers. These are generalized quantifiers defined by monoid and groupoid word-problems, equivalently, by regular and context-free languages.
Juha Kontinen, Heribert Vollmer
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Invisible pushdown languages

, 2015
Context free languages allow one to express data with hierarchical structure, at the cost of losing some of the useful properties of languages recognized by finite automata on words.
Bray T., Hopcroft J. E., Maler E., Szymanski T. G.   +3 more
core   +1 more source