Results 211 to 220 of about 1,493,771 (318)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Is het seksualiseringsproces van richting veranderd? [PDF]

, 2009
Afd ASW, Wouters, Cas, Youth in Changing Cultural Contexts   +2 more
core  

Before Copernicus and Copernicus [PDF]

Aestimatio, 2016–2018
Matjaž Vesel
doaj  

Commentary on Nieto et al.: The heterogeneity of drug craving and considerations as a treatment endpoint. [PDF]

Addiction
Strickland JC, Bergeria CL, Acuff SF.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Comment les processus de civilisation se sont-ils prolongés? De la seconde nature à la troisième nature [PDF]

, 2010
Afd ASW, Wouters, Cas, Youth in Changing Cultural Contexts   +2 more
core  

Developing Digital Self-Regulation in Adolescence: A Developmental Self-Determination Model of Digital Self-Regulation. [PDF]

Educ Psychol Rev
Wang MT.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Seksualisering is emancipatie van seksualiteit [PDF]

, 2008
Afd ASW, Wouters, Cas, Youth in Changing Cultural Contexts   +2 more
core  

Measuring readiness for disaster response in physiotherapy education: development and validation predisposition assessment tool. [PDF]

Front Public Health
Rosado MDL, Silva C, de Sá CDSC.
europepmc   +1 more source