Results 141 to 150 of about 1,436,179 (342)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Absence, presence, remembrance: A theological essay on frailty, the university and the city
Verbum et Ecclesia, 2013 This essay is reflecting on frailty, the university and the city, in relation to each other. It seeks to transcend the binary concepts of presence and absence, proposing remembrance as the frail work of making absence present, of reweaving what is ...
Stephan F. de Beer
doaj
Multi-Agent Q-Learning via Best Choice Dynamics
IEEE AccessMotivated by multi-agent Q-learning scenarios, this paper introduces a distributed action selection algorithm that relies on individual agents interacting with local neighbors to learn a joint action.
Scott Addams, Jorge Cortes
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
, 2006 The paper addresses the issue of contextual representations of ontologies, as it arises in the area of normative system specifications for modeling multiagent systems. To this aim, the paper proposes a formalization of a notion of contextual terminology, that is to say, a terminology holding only with respect to a specific context. The formalization is
Davide Grossi +2 more
openaire +5 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Contextual effects on the vote in Germany: A multilevel analysis [PDF]
This paper addresses the old topic of contextual effects on voting behaviour. Current multilevel analysis techniques provide a powerful tool to (re-)examine such regional influ-ences on individual voting decisions.
Pickery, Jan
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Ageing and implicit learning: explorations in contextual cuing [PDF]
, 2010 Research in cognitive ageing has found that while older adults show reductions in performance on standard explicit memory tasks, implicit memory performance remains relatively stable.
Smyth, A.
core