Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10 [PDF]
, 2008 Ming O. Li, Richard A. Flavell
openalex +1 more source
Oil in Venezuela: Triggering Violence or Ensuring Stability? A Context-sensitive Analysis of the Ambivalent Impact of Resource Abundance [PDF]
This paper studies the causal factors that make the oil-state Venezuela, which is generally characterized by a low level of violence, an outlier among the oil countries as a whole.
Annegret Mähler
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Contextual Factors Associated with Fecal Glucocorticoid Metabolites in Juvenile Polar Bears (Ursus maritimus) and a Cohabitating Juvenile Grizzly Bear (Ursus arctos horribilis) at the Detroit Zoo [PDF]
Emily N. Bovee +3 more
openalex +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Deconstructing and reconstructing diversity in client-provider-relationships of social work
Social Work and SocietyDiversity and reflections on diversity impact client-provider-relationships of social work on different levels, ranging from institutionalized programs to interpersonal practices to individual expectations, cognitive make-ups and emotional experiences ...
Lars Alberth +4 more
doaj
Incorporating contextual factors in back-end design stages: development and pilot testing of the Contextual Product Testing protocol [PDF]
Carlota Serrano, Grace Burleson
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source